| pubmed-article:6421522 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6421522 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:6421522 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:6421522 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:6421522 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:6421522 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6421522 | pubmed:dateCreated | 1984-4-26 | lld:pubmed |
| pubmed-article:6421522 | pubmed:abstractText | The ability of peripheral blood lymphocytes from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjogren's syndrome (SS) to produce interleukin 2 (IL-2) and respond to it in-vitro was examined. Phytohemagglutinin-stimulated lymphocytes from over half of the SLE patients exhibited a decreased ability to produce IL-2 while their concanavalin A-generated blast cells responded normally to exogenous IL-2. Lymphocytes from RA patients not only produced less IL-2 than normals (P less than 0.001), but also responded poorly to exogenous IL-2 (P = 0.011). These abnormalities did not correlate with the patient's age, sex, duration of disease, or disease activity. Production of and response to IL-2 was widely varied among patients with SS and not different from controls. The decreased response of RA lymphocytes to IL-2 may result from a smaller number of cell surface IL-2 receptors since IL-2 adsorption to RA cells was lower than to either SLE or normal cells. These data suggest that IL-2-related abnormalities may play a role in the disordered immunoregulation characteristic of RA and perhaps of SLE. | lld:pubmed |
| pubmed-article:6421522 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6421522 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421522 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6421522 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6421522 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6421522 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6421522 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:6421522 | pubmed:author | pubmed-author:TalalNN | lld:pubmed |
| pubmed-article:6421522 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
| pubmed-article:6421522 | pubmed:author | pubmed-author:RussellI JIJ | lld:pubmed |
| pubmed-article:6421522 | pubmed:author | pubmed-author:MiyasakaNN | lld:pubmed |
| pubmed-article:6421522 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6421522 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:6421522 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6421522 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6421522 | pubmed:pagination | 109-17 | lld:pubmed |
| pubmed-article:6421522 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6421522 | pubmed:meshHeading | pubmed-meshheading:6421522-... | lld:pubmed |
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| pubmed-article:6421522 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6421522 | pubmed:articleTitle | Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus. | lld:pubmed |
| pubmed-article:6421522 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6421522 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:6421522 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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