| pubmed-article:6421504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C0085180 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C2825097 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:6421504 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:6421504 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6421504 | pubmed:dateCreated | 1984-4-12 | lld:pubmed |
| pubmed-article:6421504 | pubmed:abstractText | Microsome mediated aflatoxin B1 (AFB1) binding to exogenous and endogenous DNA and its modulation by cytosolic glutathione (GSH) S-transferases have been examined in rat and hamster livers. Kinetic studies over a wide range of cytosol concentrations indicate that cytosol from the hamster is several-fold more effective than that from the rat in inhibiting AFB1 binding to exogenous calf thymus DNA mediated by microsomes from either species. Low concentrations of GSH (0.1-0.2 mM) are required for 50% inhibition of AFB1-DNA binding by cytosol. With exogenous DNA, combined microsome-cytosol fractions from the hamster give more AFB1-DNA binding than those from the rat. However, with nuclei as a source of endogenous DNA, AFB1-DNA binding is less with combined microsome-cytosol fractions from the hamster than those from the rat. Cytosolic inhibition of AFB1-DNA binding is almost completely reversed in the presence of 1 mM levels of either trichloropropene oxide or styrene oxide. Quantitation of AFB1-DNA binding and AFB1-GSH conjugation indicate an inverse relationship between these two processes. Cytosol from the rat has less capacity than that from the hamster to form an AFB1-GSH conjugate. Hepatic GSH levels are about equal (6-7 mM) in both species. I.p. administration of [14C]AFB1 2 h before sacrifice gives more AFB1 binding to hepatic nuclear DNA in rats than in hamsters. However, depletion of hepatic GSH levels by 80% by i.p. administration of diethylmaleate (600 mg/kg) increases AFB1-DNA binding 2- to 3-fold in both species. The role of cytosolic GSH S-transferases in modulating hepatic AFB1-DNA binding in rats and hamsters is discussed. | lld:pubmed |
| pubmed-article:6421504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421504 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6421504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421504 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6421504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6421504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6421504 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6421504 | pubmed:issn | 0143-3334 | lld:pubmed |
| pubmed-article:6421504 | pubmed:author | pubmed-author:LotlikarP DPD | lld:pubmed |
| pubmed-article:6421504 | pubmed:author | pubmed-author:JheeE CEC | lld:pubmed |
| pubmed-article:6421504 | pubmed:author | pubmed-author:ClearfieldM... | lld:pubmed |
| pubmed-article:6421504 | pubmed:author | pubmed-author:InsettaS MSM | lld:pubmed |
| pubmed-article:6421504 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6421504 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:6421504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6421504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6421504 | pubmed:pagination | 269-76 | lld:pubmed |
| pubmed-article:6421504 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:meshHeading | pubmed-meshheading:6421504-... | lld:pubmed |
| pubmed-article:6421504 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6421504 | pubmed:articleTitle | Modulation of microsome-mediated aflatoxin B1 binding to exogenous and endogenous DNA by cytosolic glutathione S-transferases in rat and hamster livers. | lld:pubmed |
| pubmed-article:6421504 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6421504 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6421504 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6421504 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6421504 | lld:pubmed |
