| pubmed-article:6419128 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6419128 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:6419128 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6419128 | lifeskim:mentions | umls-concept:C1366332 | lld:lifeskim |
| pubmed-article:6419128 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:6419128 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:6419128 | pubmed:issue | 5946 | lld:pubmed |
| pubmed-article:6419128 | pubmed:dateCreated | 1984-2-23 | lld:pubmed |
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| pubmed-article:6419128 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6419128 | pubmed:abstractText | During differentiation of lymphocytes into antibody-producing cells, an immunoglobulin kappa variable-region gene is transcriptionally activated by rearrangement linking it to a kappa constant (C kappa) region gene which is already transcribed prior to somatic rearrangement. The presence of a transcriptional enhancer element within the large intron of the kappa light-chain gene has been postulated to explain this mode of activation, supported by evidence of a chromatin region which is preferentially accessible to DNase I and restriction enzymes. This DNA region contains a segment of about 130 base pairs (bp) which is strongly conserved between mouse, rabbit and man. Moreover, no transcripts are detectable from a kappa gene, which is truncated within the large intron. Recently, a lymphocyte-specific enhancer has been identified downstream of the joining region in immunoglobulin heavy-chain genes. We now show direct evidence for a functionally similar enhancer within the large kappa gene intron of the mouse. It is, however, less active than the heavy-chain gene enhancer. In contrast, no enhancer was found to be associated with a cloned lambda I light-chain gene. | lld:pubmed |
| pubmed-article:6419128 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6419128 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6419128 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6419128 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6419128 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6419128 | pubmed:author | pubmed-author:SchaffnerWW | lld:pubmed |
| pubmed-article:6419128 | pubmed:author | pubmed-author:PicardDD | lld:pubmed |
| pubmed-article:6419128 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6419128 | pubmed:volume | 307 | lld:pubmed |
| pubmed-article:6419128 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6419128 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6419128 | pubmed:pagination | 80-2 | lld:pubmed |
| pubmed-article:6419128 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6419128 | pubmed:meshHeading | pubmed-meshheading:6419128-... | lld:pubmed |
| pubmed-article:6419128 | pubmed:articleTitle | A lymphocyte-specific enhancer in the mouse immunoglobulin kappa gene. | lld:pubmed |
| pubmed-article:6419128 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6419128 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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