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| pubmed-article:6418145 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6418145 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:6418145 | lifeskim:mentions | umls-concept:C0001026 | lld:lifeskim |
| pubmed-article:6418145 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:6418145 | lifeskim:mentions | umls-concept:C0080356 | lld:lifeskim |
| pubmed-article:6418145 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:6418145 | lifeskim:mentions | umls-concept:C0067724 | lld:lifeskim |
| pubmed-article:6418145 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6418145 | pubmed:dateCreated | 1984-1-7 | lld:pubmed |
| pubmed-article:6418145 | pubmed:abstractText | Valproate (0.5-5 mM) strongly inhibited urea synthesis in isolated rat hepatocytes incubated with 10 mM-alanine and 3 mM-ornithine. Valproate at the same concentrations markedly decreased concentrations of N-acetylglutamate, an essential activator of carbamoyl-phosphate synthetase I (EC 6.3.4.16), in parallel with the inhibition of urea synthesis by valproate. This compound also lowered the cellular concentration of acetyl-CoA, a substrate of N-acetylglutamate synthase (EC 2.3.1.1); glutamate, aspartate and citrulline were similarly decreased. Valproate in a dose up to 2 mM did not significantly affect the cellular concentration of ATP and had no direct effect on N-acetylglutamate synthesis, carbamoyl-phosphate synthetase I and ornithine transcarbamoylase (EC 2.1.3.3) activities. | lld:pubmed |
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| pubmed-article:6418145 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6418145 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6418145 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6418145 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6418145 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:6418145 | pubmed:author | pubmed-author:RabierDD | lld:pubmed |
| pubmed-article:6418145 | pubmed:author | pubmed-author:CoudeF XFX | lld:pubmed |
| pubmed-article:6418145 | pubmed:author | pubmed-author:ParvyPP | lld:pubmed |
| pubmed-article:6418145 | pubmed:author | pubmed-author:GrimberGG | lld:pubmed |
| pubmed-article:6418145 | pubmed:author | pubmed-author:PetitFF | lld:pubmed |
| pubmed-article:6418145 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6418145 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:6418145 | pubmed:volume | 216 | lld:pubmed |
| pubmed-article:6418145 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6418145 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6418145 | pubmed:pagination | 233-6 | lld:pubmed |
| pubmed-article:6418145 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6418145 | pubmed:meshHeading | pubmed-meshheading:6418145-... | lld:pubmed |
| pubmed-article:6418145 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6418145 | pubmed:articleTitle | Inhibition of ureagenesis by valproate in rat hepatocytes. Role of N-acetylglutamate and acetyl-CoA. | lld:pubmed |
| pubmed-article:6418145 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6418145 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:6418145 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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