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pubmed-article:6416333pubmed:abstractTextAlthough rare cases of chronic lymphocytic leukemia (CLL) of the T-cell type have been reported, CLL is more commonly found to be a neoplastic lymphoproliferative disease of B-cell origin. In this article, we describe a patient with long-standing CLL that was immunologically shown to be of the B-cell type, who, during the course of his disease, developed cutaneous T-cell lymphoma (CTCL), which was shown to be of the helper/inducer subtype. The neoplastic lymphoid cells in the skin infiltrate differed morphologically and immunologically from those in the peripheral blood. The occurrence of CTCL during this patient's clinical course represents a second neoplasm arising from a different cell line, rather than a tissue manifestation of the patient's CLL. To our knowledge, this is the first report in which the occurrence of CTCL is documented in a patient with immunologically known B-cell CLL. In addition to establishing the presence of B-cell CLL and CTCL of the helper/inducer T-cell type in the same patient, this case report demonstrates the usefulness and necessity of evaluating lymphoproliferative disorders by means of a multidisciplinary approach.lld:pubmed
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pubmed-article:6416333pubmed:pagination1176-81lld:pubmed
pubmed-article:6416333pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:6416333pubmed:articleTitleCoincidence of B-cell chronic lymphocytic leukemia and cutaneous T-cell lymphoma (mycosis fungoides): immunologic characterization by monoclonal antibodies.lld:pubmed
pubmed-article:6416333pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:6416333pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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