| pubmed-article:6407473 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6407473 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:6407473 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:6407473 | lifeskim:mentions | umls-concept:C0002272 | lld:lifeskim |
| pubmed-article:6407473 | lifeskim:mentions | umls-concept:C0052527 | lld:lifeskim |
| pubmed-article:6407473 | lifeskim:mentions | umls-concept:C0081937 | lld:lifeskim |
| pubmed-article:6407473 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:6407473 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:6407473 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6407473 | pubmed:dateCreated | 1983-7-29 | lld:pubmed |
| pubmed-article:6407473 | pubmed:abstractText | The biogenesis of three intestinal microvillar enzymes, maltase-glucoamylase (EC 3.2.1.20), aminopeptidase A (aspartate aminopeptidase, EC 3.4.11.7) and dipeptidyl peptidase IV (EC 3.4.14.5), was studied by pulse-chase labelling of pig small-intestinal explants kept in organ culture. The earliest detectable forms of the enzymes were polypeptides of Mr 225000, 140000 and 115000 respectively. These were found to represent the enzymes in a 'high-mannose' state of glycosylation, as judged by their susceptibility to treatment with endo-beta-N-acetylglucosaminidase H (EC 3.2.1.96). After about 40-60 min of chase, maltase-glucoamylase, aminopeptidase A and dipeptidyl peptidase IV were further modified to yield the mature polypeptides of Mr 245000, 170000 and 137000 respectively, which were expressed at the microvillar membrane after 60-90 min of chase. The fact that the enzymes before reaching the microvillar membrane were found in a Ca2+-precipitated membrane fraction (intracellular and basolateral membranes), but not in soluble form, indicates that during biogenesis maltase-glucoamylase, aminopeptidase A and dipeptidyl peptidase IV are transported and assembled in a membrane-bound state. | lld:pubmed |
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| pubmed-article:6407473 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6407473 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6407473 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6407473 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6407473 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6407473 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:6407473 | pubmed:author | pubmed-author:SjöströmHH | lld:pubmed |
| pubmed-article:6407473 | pubmed:author | pubmed-author:NorénOO | lld:pubmed |
| pubmed-article:6407473 | pubmed:author | pubmed-author:DanielsenE... | lld:pubmed |
| pubmed-article:6407473 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6407473 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:6407473 | pubmed:volume | 210 | lld:pubmed |
| pubmed-article:6407473 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6407473 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6407473 | pubmed:pagination | 389-93 | lld:pubmed |
| pubmed-article:6407473 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:6407473 | pubmed:meshHeading | pubmed-meshheading:6407473-... | lld:pubmed |
| pubmed-article:6407473 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6407473 | pubmed:articleTitle | Biosynthesis of intestinal microvillar proteins. Pulse-chase labelling studies on maltase-glucoamylase, aminopeptidase A and dipeptidyl peptidase IV. | lld:pubmed |
| pubmed-article:6407473 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6407473 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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