| pubmed-article:640714 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:640714 | lifeskim:mentions | umls-concept:C0038172 | lld:lifeskim |
| pubmed-article:640714 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:640714 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:640714 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:640714 | lifeskim:mentions | umls-concept:C1521801 | lld:lifeskim |
| pubmed-article:640714 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:640714 | pubmed:dateCreated | 1978-6-12 | lld:pubmed |
| pubmed-article:640714 | pubmed:abstractText | Topical oral immunization of axenic mice with non-replicating Staphylococcus aureus resulted in the production of both serum and salivary agglutinins. A latent period of approximately 5 days was noted before salivary antibodies were detected against both a carbohydrate (ChoA) and a protein (PrA) antigen isolated from this micro-organism. The local response to ChoA exhibited a linear increase until day 9 when the reciprocal titres reached a plateau [32 (16--64)]. Salivary antibodies to PrA peaked by day 13 at a mean reciprocal titre of 60 (32--128). The agglutinin response in saliva was found to be initially IgG; however, by day 9 of a 14-day-immunization regimen, IgA became the predominant class of exocrine anti-S. aureus antibodies. The serum agglutinin response followed that found in saliva by approximately 2--4 days. By day 14, all sera (6/6) contained PrA agglutinins, while 4/6 sera agglutinated sheep erythrocytes coated with ChoA. Serum antibodies to ChoA were exclusively IgM, in contrast to IgM and IgA agglutinins elicited by PrA. Absorption studies provided evidence of a specific local and systemic immune response to both ChoA and PrA antigens of perorally administered S. aureus. | lld:pubmed |
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| pubmed-article:640714 | pubmed:language | eng | lld:pubmed |
| pubmed-article:640714 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:640714 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:640714 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:640714 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:640714 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:640714 | pubmed:author | pubmed-author:MolinariJ AJA | lld:pubmed |
| pubmed-article:640714 | pubmed:author | pubmed-author:EbersoleJ LJL | lld:pubmed |
| pubmed-article:640714 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:640714 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:640714 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:640714 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:640714 | pubmed:pagination | 379-87 | lld:pubmed |
| pubmed-article:640714 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:640714 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:640714 | pubmed:articleTitle | Secretory antibody responses in axenic mice to perorally administered Staphylococcus aureus. | lld:pubmed |
| pubmed-article:640714 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:640714 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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