| pubmed-article:6401999 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6401999 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6401999 | lifeskim:mentions | umls-concept:C0004057 | lld:lifeskim |
| pubmed-article:6401999 | lifeskim:mentions | umls-concept:C0005821 | lld:lifeskim |
| pubmed-article:6401999 | lifeskim:mentions | umls-concept:C0004927 | lld:lifeskim |
| pubmed-article:6401999 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6401999 | lifeskim:mentions | umls-concept:C0057167 | lld:lifeskim |
| pubmed-article:6401999 | pubmed:dateCreated | 1983-4-7 | lld:pubmed |
| pubmed-article:6401999 | pubmed:abstractText | 1 We have studied the effects on platelet behaviour of ingestion of the thromboxane synthetase inhibitor dazoxiben (UK 37248), by healthy subjects, and compared the results with the effects of a low dose of aspirin (a cyclo-oxygenase inhibitor), and of a combination of dazoxiben and a low dose of aspirin. 2 Dazoxiben ingestion prevented the release reaction induced by sodium arachidonate (NaAA) in platelet-rich plasma (PRP) from some individuals ("responders") but not in PRP from others ("non-responders"). In vitro testing of PRP from the same subjects, incubated with 10(-4)M dazoxiben, correlated with the effect of dazoxiben ingestion on NaAA-induced release. Platelets from "non-responders" tended to undergo a more extensive release reaction than platelets from "responders" even in the absence of any drug although there was some overlap between the results in the two groups. Platelets from "non-responders" required significantly lower concentrations of NaAA to induce release reaction than platelets from "responders". Platelets from "responders" and "non-responders" did not differ in the amount of malondialdehyde (MDA) produced or in the effectiveness with which dazoxiben ingestion inhibited MDA production. 3 Low dose aspirin had comparable effects on NaAA-induced release to dazoxiben, but in contrast to dazoxiben, the effectiveness of low-dose aspirin in inhibiting NaAA induced release reaction was related to its effectiveness in inhibiting MDA generation. 4 Neither dazoxiben nor low-dose aspirin significantly affected the release reaction induced by adenosine diphosphate (ADP), although both drugs significantly inhibited adrenaline-induced release. 5 A combination of dazoxiben and low dose aspirin had a greater effect on platelet behaviour in response to NaAA, ADP, and adrenaline than either drug alone. | lld:pubmed |
| pubmed-article:6401999 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6401999 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6401999 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6401999 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6401999 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6401999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6401999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6401999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6401999 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6401999 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6401999 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:6401999 | pubmed:author | pubmed-author:HeptinstallSS | lld:pubmed |
| pubmed-article:6401999 | pubmed:author | pubmed-author:CowleyA JAJ | lld:pubmed |
| pubmed-article:6401999 | pubmed:author | pubmed-author:JonesE WEW | lld:pubmed |
| pubmed-article:6401999 | pubmed:author | pubmed-author:CockbillS RSR | lld:pubmed |
| pubmed-article:6401999 | pubmed:author | pubmed-author:HanleyS PSP | lld:pubmed |
| pubmed-article:6401999 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6401999 | pubmed:volume | 15 Suppl 1 | lld:pubmed |
| pubmed-article:6401999 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6401999 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6401999 | pubmed:pagination | 39S-44S | lld:pubmed |
| pubmed-article:6401999 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:6401999 | pubmed:meshHeading | pubmed-meshheading:6401999-... | lld:pubmed |
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| pubmed-article:6401999 | pubmed:meshHeading | pubmed-meshheading:6401999-... | lld:pubmed |
| pubmed-article:6401999 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6401999 | pubmed:articleTitle | Effects of dazoxiben and low-dose aspirin on platelet behaviour in man. | lld:pubmed |
| pubmed-article:6401999 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6401999 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6401999 | lld:pubmed |
