Linked Life Data

6391464

Source:http://linkedlifedata.com/resource/pubmed/id/6391464

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:6391464rdf:typepubmed:Citationlld:pubmed
pubmed-article:6391464lifeskim:mentionsumls-concept:C0035820lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C1280551lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0234421lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0035096lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0001563lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0005823lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0205341lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C1704632lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0871261lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0232105lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C2911692lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C1706817lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0205349lld:lifeskim
pubmed-article:6391464lifeskim:mentionsumls-concept:C0072178lld:lifeskim
pubmed-article:6391464pubmed:issue5lld:pubmed
pubmed-article:6391464pubmed:dateCreated1985-1-22lld:pubmed
pubmed-article:6391464pubmed:abstractTextThe magnitude and the persistence of blood pressure reduction by propyldazine (PDZ) was investigated following treatment over a period of 4 days. The experiments were performed on 6 normotensive dogs trained to submit to puncture of the femoral artery and to stand quietly in a special frame over the experimental period of 7 to 8 hours. The first dose effect of orally administered PDZ (0.06, 0.29 and 1.42 mg/kg) on heart rate, arterial blood pressure and plasma renin activity (PRA) was compared with the effect of the substance after treatment at the same respective dosage twice daily over 4 days. The compound caused a dose-dependent decrease in blood pressure accompanied by dose-dependent increases in heart rate and PRA. With 0.06 mg/kg and 0.29 mg/kg PDZ a sustained effect on arterial blood pressure was observed, whereas with 1.42 mg/kg PDZ tolerance occurred after treatment over the 4-day period. A comparison with the effects observed previously with 1.42 and 7.1 mg/kg dihydralazine (DHZ) under identical conditions showed similar results with respect to dose-dependence of blood pressure and counterregulation (1). It is considered that with a low-dose regimen there would be no decrease in activity of PDZ, the long-term hypotensive efficacy of the drug thereby being guaranteed.lld:pubmed
pubmed-article:6391464pubmed:languageenglld:pubmed
pubmed-article:6391464pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6391464pubmed:citationSubsetIMlld:pubmed
pubmed-article:6391464pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6391464pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6391464pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6391464pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6391464pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6391464pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:6391464pubmed:statusMEDLINElld:pubmed
pubmed-article:6391464pubmed:issn0300-8428lld:pubmed
pubmed-article:6391464pubmed:authorpubmed-author:KrauppOOlld:pubmed
pubmed-article:6391464pubmed:authorpubmed-author:RabergerGGlld:pubmed
pubmed-article:6391464pubmed:authorpubmed-author:BeckAAlld:pubmed
pubmed-article:6391464pubmed:authorpubmed-author:SeitelbergerR...lld:pubmed
pubmed-article:6391464pubmed:authorpubmed-author:BacherSSlld:pubmed
pubmed-article:6391464pubmed:issnTypePrintlld:pubmed
pubmed-article:6391464pubmed:volume79lld:pubmed
pubmed-article:6391464pubmed:ownerNLMlld:pubmed
pubmed-article:6391464pubmed:authorsCompleteYlld:pubmed
pubmed-article:6391464pubmed:pagination588-97lld:pubmed
pubmed-article:6391464pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:meshHeadingpubmed-meshheading:6391464-...lld:pubmed
pubmed-article:6391464pubmed:articleTitleAltered blood pressure response to propyldazine after repeated oral administration in conscious normotensive dogs: role of the renin-angiotensin system.lld:pubmed
pubmed-article:6391464pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:6391464pubmed:publicationTypeComparative Studylld:pubmed