| pubmed-article:6382490 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6382490 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:6382490 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:6382490 | lifeskim:mentions | umls-concept:C1157324 | lld:lifeskim |
| pubmed-article:6382490 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6382490 | pubmed:dateCreated | 1984-10-22 | lld:pubmed |
| pubmed-article:6382490 | pubmed:abstractText | The effect of cyclosporin A (CyA) treatment of rats on prostaglandin synthesis in the renal cortex was studied. Renal cortical slices were prepared from control and CyA-treated rats and the release of prostaglandins into the medium during incubation at 37 degrees was measured. Rats killed 4 hours after receiving 100 mg/kg CyA orally showed no changes in renal slice release of PGE2, PGF2 alpha, 6-keto-PGF1 alpha or thromboxane B2. The slice release of 6-keto-PGF1 alpha was tested after 5 days of CyA treatment and again there was no difference from control rats. The effect of CyA added to slice incubations in vitro was examined: CyA had no effect on PGE2 or 6-keto-PGF1 alpha release in the presence or absence of angiotensin II. Under all of these experimental conditions there was evidence of CyA-induced stimulation of the renin-angiotensin system. Indomethacin treatment did not inhibit CyA-mediated accumulation of renin in the renal cortex. The results suggest that renal prostaglandins do not play a role in CyA-stimulated renin storage or release, or in CyA nephrotoxicity. | lld:pubmed |
| pubmed-article:6382490 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6382490 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6382490 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6382490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6382490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6382490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6382490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6382490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6382490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6382490 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6382490 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6382490 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6382490 | pubmed:issn | 0034-5164 | lld:pubmed |
| pubmed-article:6382490 | pubmed:author | pubmed-author:DugginG GGG | lld:pubmed |
| pubmed-article:6382490 | pubmed:author | pubmed-author:HallB MBM | lld:pubmed |
| pubmed-article:6382490 | pubmed:author | pubmed-author:TillerD JDJ | lld:pubmed |
| pubmed-article:6382490 | pubmed:author | pubmed-author:HorvathJ SJS | lld:pubmed |
| pubmed-article:6382490 | pubmed:author | pubmed-author:BaxterC RCR | lld:pubmed |
| pubmed-article:6382490 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6382490 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:6382490 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6382490 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6382490 | pubmed:pagination | 69-80 | lld:pubmed |
| pubmed-article:6382490 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:6382490 | pubmed:meshHeading | pubmed-meshheading:6382490-... | lld:pubmed |
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| pubmed-article:6382490 | pubmed:meshHeading | pubmed-meshheading:6382490-... | lld:pubmed |
| pubmed-article:6382490 | pubmed:meshHeading | pubmed-meshheading:6382490-... | lld:pubmed |
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| pubmed-article:6382490 | pubmed:meshHeading | pubmed-meshheading:6382490-... | lld:pubmed |
| pubmed-article:6382490 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6382490 | pubmed:articleTitle | Cyclosporin A and renal prostaglandin biosynthesis. | lld:pubmed |
| pubmed-article:6382490 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6382490 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6382490 | lld:pubmed |
