| pubmed-article:6367871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C0038317 | lld:lifeskim |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C0521428 | lld:lifeskim |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C1524119 | lld:lifeskim |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C0022478 | lld:lifeskim |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C0025859 | lld:lifeskim |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C0085580 | lld:lifeskim |
| pubmed-article:6367871 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6367871 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6367871 | pubmed:dateCreated | 1984-5-17 | lld:pubmed |
| pubmed-article:6367871 | pubmed:abstractText | Treatment of fifteen patients with essential hypertension over four weeks using the beta 1-adrenoceptor blocking agent, metoprolol, resulted in a decrease in 24 h urinary excretion of kallikrein and aldosterone along with a decrease in plasma renin activity. There was no significant change in 24 h excretion rates of the free adrenal steroids deoxycorticosterone, 18-OH-deoxycorticosterone, corticosterone, cortisol or 18-OH-corticosterone during treatment, which were not significantly different from excretion rates of normal males, thus excluding inhibitory effects of adrenal steroids on urinary kallikrein activity. A positive correlation was found between plasma renin activity and urinary excretion of kallikrein during the control period and after 2 weeks on metoprolol, supporting the assumption of a preserved link between the renin-angiotensin-aldosterone system and the renal excretion of kallikrein in these patients. The decrease in kallikrein excretion during beta 1-adrenoceptor blockade in patients with essential hypertension may be explained by a reduction in sympathetic tone and by reduced activity of the renin-aldosterone system. | lld:pubmed |
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| pubmed-article:6367871 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6367871 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6367871 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6367871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6367871 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:6367871 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:6367871 | pubmed:author | pubmed-author:GotzenRR | lld:pubmed |
| pubmed-article:6367871 | pubmed:author | pubmed-author:SchöneshöferM... | lld:pubmed |
| pubmed-article:6367871 | pubmed:author | pubmed-author:FritschkaEE | lld:pubmed |
| pubmed-article:6367871 | pubmed:author | pubmed-author:KittlerRR | lld:pubmed |
| pubmed-article:6367871 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6367871 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:6367871 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6367871 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6367871 | pubmed:pagination | 245-53 | lld:pubmed |
| pubmed-article:6367871 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:6367871 | pubmed:meshHeading | pubmed-meshheading:6367871-... | lld:pubmed |
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| pubmed-article:6367871 | pubmed:meshHeading | pubmed-meshheading:6367871-... | lld:pubmed |
