pubmed-article:6330090 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6330090 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
pubmed-article:6330090 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:6330090 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
pubmed-article:6330090 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
pubmed-article:6330090 | lifeskim:mentions | umls-concept:C0029282 | lld:lifeskim |
pubmed-article:6330090 | pubmed:issue | 12 | lld:pubmed |
pubmed-article:6330090 | pubmed:dateCreated | 1984-7-30 | lld:pubmed |
pubmed-article:6330090 | pubmed:abstractText | Ornithine decarboxylase, the first enzyme of the polyamine biosynthetic pathway, is induced by androgens in the mouse kidney. We have isolated from a kidney cDNA clone bank two plasmids, pODC1440 and pODC934 , that contain different cDNA inserts corresponding to ornithine decarboxylase mRNA. Identification was based upon the ability of plasmid-specific mRNAs to encode a 53,000-dalton polypeptide that reacts with antibody to purified mouse kidney ornithine decarboxylase. Plasmid pODC1440 hybridizes predominantly to a mRNA that is 2.1 kilobases (kb) long and is induced about 20-fold in the kidneys of female mice treated with testosterone. Plasmid pODC934 hybridizes to mRNAs of lengths 2.2 and 2.6 kb, which are induced about 8-fold by testosterone. There are probably no more than 1-2 copies of the pODC1440 -specific sequence in the mouse genome, while there may be as many as 12 copies of the pODC934 -specific sequence. That the two plasmids correspond to different ornithine decarboxylase mRNAs is suggested by two observations. First, several mouse strains express normal levels of pODC934 -specific RNA and little or no pODC1440 -specific RNA; furthermore, pODC934 -specific RNA is expressed in several tissues while pODC1440 -specific RNA is kidney-specific. Thus, androgen-mediated stimulation of kidney ornithine decarboxylase activity levels involves alterations in the concentrations of at least two distinct mRNAs. | lld:pubmed |
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pubmed-article:6330090 | pubmed:language | eng | lld:pubmed |
pubmed-article:6330090 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6330090 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:6330090 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6330090 | pubmed:month | Jun | lld:pubmed |
pubmed-article:6330090 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:6330090 | pubmed:author | pubmed-author:WatsonGG | lld:pubmed |
pubmed-article:6330090 | pubmed:author | pubmed-author:BergerF GFG | lld:pubmed |
pubmed-article:6330090 | pubmed:author | pubmed-author:TomaJ JJJJr | lld:pubmed |
pubmed-article:6330090 | pubmed:author | pubmed-author:SzymanskiPP | lld:pubmed |
pubmed-article:6330090 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6330090 | pubmed:day | 25 | lld:pubmed |
pubmed-article:6330090 | pubmed:volume | 259 | lld:pubmed |
pubmed-article:6330090 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6330090 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6330090 | pubmed:pagination | 7941-6 | lld:pubmed |
pubmed-article:6330090 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:6330090 | pubmed:meshHeading | pubmed-meshheading:6330090-... | lld:pubmed |
pubmed-article:6330090 | pubmed:year | 1984 | lld:pubmed |
pubmed-article:6330090 | pubmed:articleTitle | Androgen-regulated ornithine decarboxylase mRNAs of mouse kidney. | lld:pubmed |
pubmed-article:6330090 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6330090 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
entrez-gene:18263 | entrezgene:pubmed | pubmed-article:6330090 | lld:entrezgene |
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