| pubmed-article:6321590 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C0231330 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C0000530 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C0020852 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C0085732 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C1149915 | lld:lifeskim |
| pubmed-article:6321590 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:6321590 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6321590 | pubmed:dateCreated | 1984-4-24 | lld:pubmed |
| pubmed-article:6321590 | pubmed:abstractText | Ecto-5'-nucleotidase activity was measured in peripheral blood lymphocytes isolated from serial specimens from nine healthy full-term infants and two premature infants at 0, 2, 4, and 6 mo of age. The postnatal nadir in activity was 7.1 +/- 2.0 nmol/hr/10(6) cells, which is the same as the activity in cord blood lymphocytes (7.0 +/- 2 nmol/hr/10(6) cells). The activity rose twofold to 13.2 +/- 3.8 nmol/hr/10(6) cells at 6 mo of age (p less than 0.001, paired t-test), which is similar to the activity in adult peripheral blood lymphocytes (14.1 +/- 6.3 nmol/hr/10(6) cells). This increased activity in total lymphocytes reflects increased activity in the B cell population. B cell ecto-5'-nucleotidase activity in two infants at 12 to 13 mo of age was 19.3 and 25.2 nmol/hr/10(6) cells, values that are four-to fivefold higher than for cord blood B cells (5.6 +/- 2.8 nmol/hr/10(6) cells) and within the normal range for adult B cells (27.9 +/- 12 nmol/hr/10(6) cells). In spite of a greatly expanded peripheral blood B cell population, studies of immunoglobulin biosynthesis in vitro demonstrated that infant peripheral blood B cells are functionally immature with no synthesis of IgG in response to Epstein Barr virus. Thus, the increase in peripheral blood B lymphocyte ecto-5'-nucleotidase activity in infants precedes their acquisition of a capacity for IgG synthesis in vitro. Data from a hypogammaglobulinemic infant revealed a persistently low ecto-5'-nucleotidase activity over a 10-mo period until at 14 mo of age the activity was 8.8 nmol/hr/10(6) cells in total lymphocytes and 13.0 nmol/hr/10(6) cells in B cells, which correlated with in vivo and in vitro evidence of delayed B cell maturation. Thus, ecto-5'-nucleotidase activity may be a useful cell surface marker in studies of human postnatal B cell maturation. | lld:pubmed |
| pubmed-article:6321590 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321590 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321590 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6321590 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6321590 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6321590 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6321590 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6321590 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6321590 | pubmed:author | pubmed-author:ThompsonL FLF | lld:pubmed |
| pubmed-article:6321590 | pubmed:author | pubmed-author:O'ConnorR DRD | lld:pubmed |
| pubmed-article:6321590 | pubmed:author | pubmed-author:RuediJ MJM | lld:pubmed |
| pubmed-article:6321590 | pubmed:author | pubmed-author:BastianJ FJF | lld:pubmed |
| pubmed-article:6321590 | pubmed:author | pubmed-author:MacPhersonG... | lld:pubmed |
| pubmed-article:6321590 | pubmed:author | pubmed-author:GolembeskyH... | lld:pubmed |
| pubmed-article:6321590 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6321590 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:6321590 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6321590 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6321590 | pubmed:pagination | 1767-72 | lld:pubmed |
| pubmed-article:6321590 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6321590 | pubmed:meshHeading | pubmed-meshheading:6321590-... | lld:pubmed |
| pubmed-article:6321590 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6321590 | pubmed:articleTitle | Lymphocyte ecto-5'-nucleotidase activity in infancy: increasing activity in peripheral blood B cells precedes their ability to synthesize IgG in vitro. | lld:pubmed |
| pubmed-article:6321590 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6321590 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6321590 | pubmed:publicationType | Case Reports | lld:pubmed |
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