| pubmed-article:6320164 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0032868 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0206558 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0042216 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0019168 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0017387 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C1514798 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C2608085 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C1824884 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0042211 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C1527177 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0441513 | lld:lifeskim |
| pubmed-article:6320164 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:6320164 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6320164 | pubmed:dateCreated | 1984-3-1 | lld:pubmed |
| pubmed-article:6320164 | pubmed:abstractText | Potential live vaccines using recombinant vaccinia viruses have been constructed for both hepatitis B and herpes simplex. These recombinant vaccinia viruses express cloned genes of the hepatitis B virus surface antigen (HBsAg) or the glycoprotein D from herpes simplex virus (HSV-gD). The HBsAg synthesized in vitro under the regulation of vaccinia virus is secreted from infected cells as a particle of approximately equal to 22 nm diameter with a density of 1.2 g/ml as determined on CsCl gradients. Inoculation of rabbits with the recombinant vaccinia virus that expresses the HBsAg elicits the production of high-titered antibodies. Synthesis of the HSV-gD was detected in tissue culture by radioimmunoassay on unfixed cells, suggesting that the HSV-gD synthesized by the recombinant vaccinia virus is membrane associated. Inoculation of rabbits with the recombinant vaccinia virus expressing HSV-gD resulted in the production of antibodies that reacted with authentic HSV-gD as detected by radioimmunoassay. Furthermore, the anti-serum was shown by plaque-reduction assay to neutralize the infectivity of herpes simplex virus. Immunization of mice with the vaccinia recombinant expressing HSV-gD gave complete protection on subsequent challenge with lethal doses of live herpes simplex virus. | lld:pubmed |
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| pubmed-article:6320164 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6320164 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6320164 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6320164 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6320164 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:6320164 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6320164 | pubmed:author | pubmed-author:MercerSS | lld:pubmed |
| pubmed-article:6320164 | pubmed:author | pubmed-author:PaolettiEE | lld:pubmed |
| pubmed-article:6320164 | pubmed:author | pubmed-author:LipinskasB... | lld:pubmed |
| pubmed-article:6320164 | pubmed:author | pubmed-author:PanicaliDD | lld:pubmed |
| pubmed-article:6320164 | pubmed:author | pubmed-author:SamsonoffCC | lld:pubmed |
| pubmed-article:6320164 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6320164 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:6320164 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6320164 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6320164 | pubmed:pagination | 193-7 | lld:pubmed |
| pubmed-article:6320164 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6320164 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6320164 | pubmed:articleTitle | Construction of live vaccines using genetically engineered poxviruses: biological activity of vaccinia virus recombinants expressing the hepatitis B virus surface antigen and the herpes simplex virus glycoprotein D. | lld:pubmed |
| pubmed-article:6320164 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6320164 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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