| pubmed-article:6319495 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0029974 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0745754 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0036315 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:6319495 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:6319495 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6319495 | pubmed:dateCreated | 1984-3-23 | lld:pubmed |
| pubmed-article:6319495 | pubmed:abstractText | Previously, it was shown that macrophages isolated from liver granulomas of Schistosoma mansoni-infected mice constituted about 30% of the granuloma cell population, were highly activated, and more than 50% displayed H-2 I region-associated antigens. Moreover, the degree of macrophage maturation/activation correlated with the intensity of the granulomatous response. Thus, inflammatory macrophages from the vigorous granulomas of acutely infected mice (VigGrM phi) displayed greater phagocytic and tumoricidal activity than did M phi from the T suppressor cell-modulated granulomas (ModGrM phi) of chronically infected animals. No difference was seen, however, in the percentage of Ia-bearing M phi isolated from vigorous or modulated liver granulomas. Presently, accessory activity of GrM phi was assayed by reconstitution of the proliferative responses of M phi-depleted lymphocytes. Both VigGrM phi and ModGrM phi were able to reconstitute the Con-A induced proliferation of normal thymoctyes. Moreover, both types of GrM phi could reconstitute parasite egg antigen-specific proliferation of the mesenteric lymph node cells from acutely infected mice. Reconstitution was dependent on M phi that displayed I-A and I-E subregion-encoded determinants. In higher doses the activated VigGrM phi were more suppressive toward lymphocytic proliferation than were the less activated ModGrM phi. Apparently, the degree of M phi suppressor activity was in direct relationship to the state of M phi maturation/activation. These data indicate that the inflammatory M phi of the schistosome granuloma may be involved in the focal immune accessory/regulatory events that occur within these T cell-mediated lesions. | lld:pubmed |
| pubmed-article:6319495 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6319495 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6319495 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6319495 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6319495 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6319495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6319495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6319495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6319495 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6319495 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6319495 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6319495 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6319495 | pubmed:author | pubmed-author:BoothG HGH | lld:pubmed |
| pubmed-article:6319495 | pubmed:author | pubmed-author:ElliottD EDE | lld:pubmed |
| pubmed-article:6319495 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6319495 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:6319495 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6319495 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6319495 | pubmed:pagination | 1506-10 | lld:pubmed |
| pubmed-article:6319495 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:meshHeading | pubmed-meshheading:6319495-... | lld:pubmed |
| pubmed-article:6319495 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6319495 | pubmed:articleTitle | Schistosome egg antigen(s) presentation and regulatory activity by macrophages isolated from vigorous or immunomodulated liver granulomas of Schistosoma mansoni-infected mice. | lld:pubmed |
| pubmed-article:6319495 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6319495 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6319495 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6319495 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6319495 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6319495 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6319495 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6319495 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6319495 | lld:pubmed |
