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pubmed-article:63167pubmed:dateCreated1977-1-29lld:pubmed
pubmed-article:63167pubmed:abstractTextThe immunopathology of five cases of spontaneous allograft rupture has been studied. All kidneys were edematous on exploration and routine histological sections showed interstitial edema and mononuclear cell infiltration characteristic of acute rejection. Immunofluorescence revealed, at most, scattered vascular deposition of IgM and mild mesangial C3 deposition. These findings are compared with findings in normal kidneys and kidneys which had been hyperacutely rejected. The normal kidney showed focal afferent arteriolar and proximal mesangial stalk deposition of C3 without IgM. The kidneys of patients with hyperacute rejection showed brilliant staining for fibrin and IgM in all arterial and arteriolar walls with lesser amounts of C3 and IgG; IgM and C3 were prominent in the glomerulus. These findings suggest that mechanisms other than circulating preformed antibodies are responsible for the pathogenesis of spontaneous allograft rupture.lld:pubmed
pubmed-article:63167pubmed:languageenglld:pubmed
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pubmed-article:63167pubmed:statusMEDLINElld:pubmed
pubmed-article:63167pubmed:monthNovlld:pubmed
pubmed-article:63167pubmed:issn0041-1337lld:pubmed
pubmed-article:63167pubmed:authorpubmed-author:NajarianJ SJSlld:pubmed
pubmed-article:63167pubmed:authorpubmed-author:SimmonsR LRLlld:pubmed
pubmed-article:63167pubmed:authorpubmed-author:MatasA JAJlld:pubmed
pubmed-article:63167pubmed:authorpubmed-author:MosesS WSWlld:pubmed
pubmed-article:63167pubmed:authorpubmed-author:ScheinmanJ...lld:pubmed
pubmed-article:63167pubmed:authorpubmed-author:RattazziL CLClld:pubmed
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pubmed-article:63167pubmed:volume22lld:pubmed
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pubmed-article:63167pubmed:pagination420-6lld:pubmed
pubmed-article:63167pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:63167pubmed:year1976lld:pubmed
pubmed-article:63167pubmed:articleTitleImmunopathological studies of the ruptured human renal allograft.lld:pubmed
pubmed-article:63167pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:63167pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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