| pubmed-article:6311275 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6311275 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6311275 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6311275 | lifeskim:mentions | umls-concept:C0001625 | lld:lifeskim |
| pubmed-article:6311275 | lifeskim:mentions | umls-concept:C0023820 | lld:lifeskim |
| pubmed-article:6311275 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:6311275 | lifeskim:mentions | umls-concept:C0001655 | lld:lifeskim |
| pubmed-article:6311275 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6311275 | lifeskim:mentions | umls-concept:C1149836 | lld:lifeskim |
| pubmed-article:6311275 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6311275 | pubmed:dateCreated | 1983-11-23 | lld:pubmed |
| pubmed-article:6311275 | pubmed:abstractText | Hypercortisolism was induced in rats by the administration of a corticotrophin analogue (Synacthen depot). The effect of this treatment during different periods was studied in normally fed and overnight-fasted rats. The activity of liver-type lipases, i.e., of lipases similar to the heparin-releasable lipase of rat liver (liver lipase), was determined in the adrenal gland and in the liver. Short-term (16 h) treatment had no effect on the lipase activity in the adrenal gland. During prolonged treatment, however, the lipase activity rose to 600-700% of control values in 10 days and from then on remained constant. The effect was similar in fed and overnight-fasted rats. The lipase activity in the liver decreased upon Synacthen administration. In the fed rats a decrease of 25% of the initial value was found after 16 h, 40% after 3 days and 50% after 20 days of treatment. In overnight-fasted rats the lowering of the lipase activity was less marked than in fasted controls. Serum lipid levels and high-density lipoprotein (HDL) subclass concentrations were also measured. The cholesterol concentration in the lipoproteins with a density greater than 1.050 g/ml (HDL) was elevated in rats treated for 3-20 days. If the rats were treated for longer than 10 days, overnight fasting led to a normalization of the HDL-cholesterol levels. After separation of the HDL into two subfractions, a relatively 'light' apolipoprotein E-rich fraction and a more 'heavy' apolipoprotein A-I-rich fraction, in fed and fasted animals treated with Synacthen for 3 days both HDL subfractions were elevated. After 10 days treatment only the apolipoprotein A-I-rich HDL fraction was still enhanced in both fed and fasted rats. | lld:pubmed |
| pubmed-article:6311275 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6311275 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6311275 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6311275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6311275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6311275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6311275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6311275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6311275 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6311275 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6311275 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6311275 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:6311275 | pubmed:author | pubmed-author:JansenHH | lld:pubmed |
| pubmed-article:6311275 | pubmed:author | pubmed-author:De GreefW JWJ | lld:pubmed |
| pubmed-article:6311275 | pubmed:author | pubmed-author:Schoonderwoer... | lld:pubmed |
| pubmed-article:6311275 | pubmed:author | pubmed-author:BaggenM GMG | lld:pubmed |
| pubmed-article:6311275 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6311275 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:6311275 | pubmed:volume | 753 | lld:pubmed |
| pubmed-article:6311275 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6311275 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6311275 | pubmed:pagination | 205-12 | lld:pubmed |
| pubmed-article:6311275 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:6311275 | pubmed:meshHeading | pubmed-meshheading:6311275-... | lld:pubmed |
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| pubmed-article:6311275 | pubmed:meshHeading | pubmed-meshheading:6311275-... | lld:pubmed |
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| pubmed-article:6311275 | pubmed:meshHeading | pubmed-meshheading:6311275-... | lld:pubmed |
| pubmed-article:6311275 | pubmed:meshHeading | pubmed-meshheading:6311275-... | lld:pubmed |
| pubmed-article:6311275 | pubmed:meshHeading | pubmed-meshheading:6311275-... | lld:pubmed |
| pubmed-article:6311275 | pubmed:meshHeading | pubmed-meshheading:6311275-... | lld:pubmed |
| pubmed-article:6311275 | pubmed:meshHeading | pubmed-meshheading:6311275-... | lld:pubmed |
| pubmed-article:6311275 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6311275 | pubmed:articleTitle | The effect of corticotrophin on liver-type lipase activity in adrenals, liver and high-density lipoprotein subfractions in the rat. | lld:pubmed |
| pubmed-article:6311275 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6311275 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6311275 | lld:pubmed |
