| pubmed-article:6302699 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0242275 | lld:lifeskim |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0929301 | lld:lifeskim |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0006141 | lld:lifeskim |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:6302699 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:6302699 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:6302699 | pubmed:dateCreated | 1983-6-10 | lld:pubmed |
| pubmed-article:6302699 | pubmed:abstractText | Normal murine mammary epithelial cells possessed the capacity to bind epidermal growth factor (EGF) in a specific and saturable manner. Scatchard plot analysis showed a curvilinear pattern. Assuming that this is not due to negative cooperativity of EGF binding, the data suggest the presence of two classes of receptors with a high and a low affinity: Kd values = 1 x 10(-10)M and 3.6 x 10(-9)M, respectively. The number of high- and low-affinity receptors was estimated to be 800 per cell and 8,600 per cell, respectively. The occupancy of EGF receptors for a half-maximal stimulation of DNA synthesis or inhibition of casein synthesis was about 10% and 6% of total receptors, respectively. A potent tumor promoter, 12-O-tetradecanoylphorbol 13-acetate, acted synergistically with EGF in terms of stimulation of DNA synthesis but not in terms of inhibition of casein synthesis when the two agents were added at a suboptimal concentration. The presence of the tumor promoter increased the amount of EGF bound to mammary cells in culture and also decreased a loss in the amount of EGF in the culture medium. These results indicate that mammary epithelial cells possess functional receptors for EGF, which are modulated by the tumor promoter. | lld:pubmed |
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| pubmed-article:6302699 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6302699 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6302699 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6302699 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6302699 | pubmed:month | May | lld:pubmed |
| pubmed-article:6302699 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6302699 | pubmed:author | pubmed-author:OkaTT | lld:pubmed |
| pubmed-article:6302699 | pubmed:author | pubmed-author:TaketaniYY | lld:pubmed |
| pubmed-article:6302699 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6302699 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:6302699 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6302699 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6302699 | pubmed:pagination | 2647-50 | lld:pubmed |
| pubmed-article:6302699 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:6302699 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6302699 | pubmed:articleTitle | Biological action of epidermal growth factor and its functional receptors in normal mammary epithelial cells. | lld:pubmed |
| pubmed-article:6302699 | pubmed:publicationType | Journal Article | lld:pubmed |
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