| pubmed-article:630130 | pubmed:abstractText | The canine posterior vena cava was excised and divided into three embryologically distinct segments: segment A (supradiaphragm), segment B-C (intrahepatic and that between liver and renal veins), and segment D (infrarenal). Circular and longitudinal strips were cut from each segment, suspended in Krebs bicarbonate solution and isometric tensions were recorded. The responses to six vasoactive agents, as well as transmural neural stimulation were studied. Maximum tension and ED50 were obtained for norepinephrine, epinephrine, acetylcholine, bradykinin, histamine and 5-hydroxytryptamine (5-HT). The responses were not only quantitatively, but qualitatively different among the three segments. Bradykinin constricted the strips in A and B-C but not in D. 5-HT (less than 10(-5) M) caused a dose-dependent contraction in A and D through its direct stimulating action, while in C, a contractile response appeared only after administration of a higher dose of 5-HT. This was due to an indirect sympathomimetic action of the agent. Segment B-C, which histologically contained massive longitudinal muscle bundles in the outer layer of the wall, exhibited spontaneous, rhythmic contractions. The existence of a cholinergic excitatory innervation, in addition to adrenergic, was demonstrated in C by transmural neural stimulation. | lld:pubmed |
