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pubmed-article:6297693pubmed:abstractTextSodium periodate treatment of Mouse spleen cells activated suppressor cells which act on the in vitro antibody response towards sheep erythrocytes or trinitrophenyl-polyacrylamide beads. Present study shows that suppression can be mediated by soluble factor (s) released in the cultures of periodate treated cells. Production of such suppressor factor (s) was associated to the presence of free aldehyde groups generated by periodate on the lymphocyte membrane. Control or cells successively treated by periodate and then reduced by borohydride were unable to produce suppressor factor (s). Suppressor factor (s) were stable at 56 degrees C (30 mn) and inactivated at 80 degrees C (10 mn).lld:pubmed
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pubmed-article:6297693pubmed:articleTitle[Production of suppressor factor(s) in the in vitro antibody response by periodate oxidized spleen cells].lld:pubmed
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