| pubmed-article:6291785 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6291785 | lifeskim:mentions | umls-concept:C0000742 | lld:lifeskim |
| pubmed-article:6291785 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:6291785 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:6291785 | lifeskim:mentions | umls-concept:C1511695 | lld:lifeskim |
| pubmed-article:6291785 | lifeskim:mentions | umls-concept:C0549178 | lld:lifeskim |
| pubmed-article:6291785 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6291785 | pubmed:dateCreated | 1983-1-27 | lld:pubmed |
| pubmed-article:6291785 | pubmed:abstractText | A cell line transformed by Abelson murine leukemia virus, called PD, is capable of carrying out kappa-gene rearrangement while growing in culture. Subclones of PD have diverse kappa-gene structures, and some derivatives show evidence of continued joining activity after as many as three subclonings. Analysis of PD sublineages has shown that a rearranged chromosome can undergo secondary kappa-gene rearrangements, producing either a new rearrangement or a deletion of C kappa. Although the PD line actively rearranges its kappa genes, its rearranged heavy-chain genes show little variation, and there is no rearrangement of lambda genes. In PD subclones, DNA fragments representing the reciprocal product of kappa-gene rearrangement are often evident, and they may undergo either further rearrangement or deletion. The implications of multiple rearrangements on a single chromosome and of the maintenance of reciprocal fragments are considered in the context of a model that postulates that the V kappa and J kappa segments are not all organized in the DNA in the same transcriptional direction, leading to inversions rather than deletions during joining. | lld:pubmed |
| pubmed-article:6291785 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6291785 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6291785 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6291785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6291785 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6291785 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6291785 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6291785 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:6291785 | pubmed:author | pubmed-author:BaltimoreDD | lld:pubmed |
| pubmed-article:6291785 | pubmed:author | pubmed-author:LewisSS | lld:pubmed |
| pubmed-article:6291785 | pubmed:author | pubmed-author:RosenbergNN | lld:pubmed |
| pubmed-article:6291785 | pubmed:author | pubmed-author:AltFF | lld:pubmed |
| pubmed-article:6291785 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6291785 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:6291785 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6291785 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6291785 | pubmed:pagination | 807-16 | lld:pubmed |
| pubmed-article:6291785 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6291785 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6291785 | pubmed:articleTitle | Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus. | lld:pubmed |
| pubmed-article:6291785 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6291785 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6291785 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:6291785 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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