| pubmed-article:6286948 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C0006684 | lld:lifeskim |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C0013030 | lld:lifeskim |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C0229531 | lld:lifeskim |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6286948 | lifeskim:mentions | umls-concept:C0376249 | lld:lifeskim |
| pubmed-article:6286948 | pubmed:dateCreated | 1982-10-29 | lld:pubmed |
| pubmed-article:6286948 | pubmed:abstractText | 1. Spontaneous discharge of action potentials (Na spikes) in cells isolated from rat pars intermedia was slowed or arrested by Co(2+), Ni(2+) or Mn(2+), which block voltage-dependent Ca channels in these cells. The amplitude of persisting spikes was undiminished. The effects resembled those of dopamine.2. Action potential frequency decreased when the Ca(2+) concentration was lowered to 0.1 mM and increased when the Ca(2+) concentration was raised from this level to 1 mM or 2 mM or when Ba(2+) (2 mM) was introduced. These effects, together with those of Co(2+), Ni(2+) and Mn(2+), are consistent with the possibility that Ca(2+) participates in the regulation of spike discharge.3. Verapamil, methoxyverapamil (D600), and nifedipine reduced the amplitude of the individual Na spikes in concentrations that had little effect on voltage-dependent Ca channels. Action potential frequency was comparatively little affected by these drugs.4. K(+) (15 mM) stimulated action potential frequency and this effect too was suppressed by dopamine or Co(2+).5. The effect which dopamine had of slowing spontaneous discharge, like the inhibitory effect on secretion, was blocked by metoclopramide. But otherwise the mechanism is unclear: dopamine blocked voltage-dependent Ca channels in some cells but not in most others.6. The effects of K(+) and Ba(2+) of eliciting spikes, the suppression of Na-spike discharge by Co(2+) and related Ca-channel blocking cations, and the unspecific effects of the organic ;Ca channel blockers', all have implications for the use of these substances as tools to analyse stimulus-secretion coupling. | lld:pubmed |
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| pubmed-article:6286948 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6286948 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6286948 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6286948 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6286948 | pubmed:month | May | lld:pubmed |
| pubmed-article:6286948 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:6286948 | pubmed:author | pubmed-author:DouglasW WWW | lld:pubmed |
| pubmed-article:6286948 | pubmed:author | pubmed-author:TaraskevichP... | lld:pubmed |
| pubmed-article:6286948 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6286948 | pubmed:volume | 326 | lld:pubmed |
| pubmed-article:6286948 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6286948 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6286948 | pubmed:pagination | 201-11 | lld:pubmed |
| pubmed-article:6286948 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6286948 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6286948 | pubmed:articleTitle | Slowing effects of dopamine and calcium-channel blockers on frequency of sodium spikes in rat pars intermedia cells. | lld:pubmed |
| pubmed-article:6286948 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6286948 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:6286948 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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