| pubmed-article:6283233 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6283233 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:6283233 | lifeskim:mentions | umls-concept:C0027713 | lld:lifeskim |
| pubmed-article:6283233 | lifeskim:mentions | umls-concept:C0205108 | lld:lifeskim |
| pubmed-article:6283233 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:6283233 | lifeskim:mentions | umls-concept:C0204592 | lld:lifeskim |
| pubmed-article:6283233 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:6283233 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6283233 | pubmed:dateCreated | 1982-8-14 | lld:pubmed |
| pubmed-article:6283233 | pubmed:abstractText | Renal tubular function was studied in 14 patients chronically treated with lithium for affective disorders. Patients were separated into two groups according to the duration of lithium therapy: long-term (35 +/- 7.0 months) and short-term (4.8 +/- 0.8 months). At comparable urine lithium concentrations, patients on long-term therapy had a lower maximal urine osmolality (Umax) and free water reabsorption (TcH2O) than did patients on short-term therapy. The latter group achieved a Umax above 800 mOsm kg H2O. In contrast, both groups of patients failed to increase the urine-blood (U-B) Pco2 gradient normally during acute sodium bicarbonate loading. This low U-B Pco2 was observed at comparable urine bicarbonate concentrations between both groups of patients and controls, and thus was associated with a higher urine pH in patients. These findings indicate that the inability of these patients to achieve a normal U-B Pco2 in a maximally alkaline urine was the result of decreased distal hydrogen ion secretion rather than inability to raise urine bicarbonate concentrations as a result of a concentrating defect. Bicarbonate reabsorptive capacity was normal in our lithium-treated subjects. Both groups of patients achieved a normal U-B Pco2 gradient in response to sodium phosphate loading. They also were able to achieve a minimal urine pH and a maximal acid excretion similar to those of controls in response to a 3-day ammonium chloride loading test. Our data demonstrate that chronic lithium therapy is associated with a mild distal acidification defect disclosed only by the finding of a low U-B Pco2 gradient during sodium bicarbonate loading. This peculiar defect can be found in short-term lithium-treated patients in whom the concentrating capacity is relatively well preserved. | lld:pubmed |
| pubmed-article:6283233 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6283233 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6283233 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6283233 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6283233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6283233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6283233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6283233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6283233 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6283233 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6283233 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6283233 | pubmed:issn | 0085-2538 | lld:pubmed |
| pubmed-article:6283233 | pubmed:author | pubmed-author:KurtzmanN ANA | lld:pubmed |
| pubmed-article:6283233 | pubmed:author | pubmed-author:ArrudaJ AJA | lld:pubmed |
| pubmed-article:6283233 | pubmed:author | pubmed-author:WynnJJ | lld:pubmed |
| pubmed-article:6283233 | pubmed:author | pubmed-author:GaviriaMM | lld:pubmed |
| pubmed-article:6283233 | pubmed:author | pubmed-author:GrupsJJ | lld:pubmed |
| pubmed-article:6283233 | pubmed:author | pubmed-author:BatlleDD | lld:pubmed |
| pubmed-article:6283233 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6283233 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:6283233 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6283233 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6283233 | pubmed:pagination | 477-85 | lld:pubmed |
| pubmed-article:6283233 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6283233 | pubmed:meshHeading | pubmed-meshheading:6283233-... | lld:pubmed |
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| pubmed-article:6283233 | pubmed:meshHeading | pubmed-meshheading:6283233-... | lld:pubmed |
| pubmed-article:6283233 | pubmed:meshHeading | pubmed-meshheading:6283233-... | lld:pubmed |
| pubmed-article:6283233 | pubmed:meshHeading | pubmed-meshheading:6283233-... | lld:pubmed |
| pubmed-article:6283233 | pubmed:meshHeading | pubmed-meshheading:6283233-... | lld:pubmed |
| pubmed-article:6283233 | pubmed:meshHeading | pubmed-meshheading:6283233-... | lld:pubmed |
| pubmed-article:6283233 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6283233 | pubmed:articleTitle | Distal nephron function in patients receiving chronic lithium therapy. | lld:pubmed |
| pubmed-article:6283233 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6283233 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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