| pubmed-article:6272298 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6272298 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:6272298 | lifeskim:mentions | umls-concept:C0815000 | lld:lifeskim |
| pubmed-article:6272298 | lifeskim:mentions | umls-concept:C0032821 | lld:lifeskim |
| pubmed-article:6272298 | lifeskim:mentions | umls-concept:C0034414 | lld:lifeskim |
| pubmed-article:6272298 | lifeskim:mentions | umls-concept:C1524062 | lld:lifeskim |
| pubmed-article:6272298 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:6272298 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:6272298 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:6272298 | pubmed:dateCreated | 1982-1-20 | lld:pubmed |
| pubmed-article:6272298 | pubmed:abstractText | Quinine and quinidine have been evaluated with regard to their effects on the electrical activity of neuroblastoma cells. Under voltage-clamp conditions, we have found that quinine and quinidine block both the voltage-dependent and Ca2+-dependent K+ conductances. Blockage of the voltage-dependent K+ channel is manifest as an increase in the amplitude and in the duration of the action potential. Blockage of the Ca2+-dependent K+ channel in Na+-free (replaced by Tris) solutions containing 6.8 mM Ca2+ and tetraethylammonium ion or 4-aminopyridine (to block the voltage-dependent K+ current) is seen as a further prolongation of the Ca2+ action potential and diminution of the after-hyperpolarization. A critical role of the Ca2+-dependent K+ conductance in modulation of the rate and duration of trains of Ca2+ action potentials is shown by the use of low concentrations (5-40 microM) of quinine or quinidine, which diminish the Ca2+-dependent K+ conductance in a graded manner. After complete blockade of K+ currents, the peak Ca2+ currents are enhanced at all voltages, especially at values more positive than -30 mV, where a steady-state inward current appears as well. In this same voltage range, the decay of the Ca2+ current exhibits two time constants--that of the transient inward current, which is about 20 msec, and a much slower (approximately 2000 msec) component. It is suggested that neuroblastoma cells have two types of calcium channels--one which generates the Ca2+ action potential and a second, distinguished by activation at more depolarized levels and by a slow rate of inactivation, which underlies the calcium entry necessary to activate the Ca2+-dependent K+ conductance. | lld:pubmed |
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| pubmed-article:6272298 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6272298 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6272298 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6272298 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6272298 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6272298 | pubmed:author | pubmed-author:SpectorII | lld:pubmed |
| pubmed-article:6272298 | pubmed:author | pubmed-author:FishmanM CMC | lld:pubmed |
| pubmed-article:6272298 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6272298 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:6272298 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6272298 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6272298 | pubmed:pagination | 5245-9 | lld:pubmed |
| pubmed-article:6272298 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6272298 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6272298 | pubmed:articleTitle | Potassium current suppression by quinidine reveals additional calcium currents in neuroblastoma cells. | lld:pubmed |
| pubmed-article:6272298 | pubmed:publicationType | Journal Article | lld:pubmed |
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