| pubmed-article:6271251 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6271251 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6271251 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:6271251 | lifeskim:mentions | umls-concept:C0017776 | lld:lifeskim |
| pubmed-article:6271251 | lifeskim:mentions | umls-concept:C0033384 | lld:lifeskim |
| pubmed-article:6271251 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6271251 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:6271251 | lifeskim:mentions | umls-concept:C0003865 | lld:lifeskim |
| pubmed-article:6271251 | lifeskim:mentions | umls-concept:C0687080 | lld:lifeskim |
| pubmed-article:6271251 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6271251 | pubmed:dateCreated | 1982-1-20 | lld:pubmed |
| pubmed-article:6271251 | pubmed:abstractText | The collagenolytic activity associated with insoluble collagen fibers separated from homogenates of inflamed paws from rats with adjuvant arthritis was quantitated using EDTA-sensitive solubilization of hydroxyproline as a measure of activity. Approximately 60% of the solubilized hydroxyproline was associated with dialyzable products. The level of collagenolytic activity in the paws increased with time after the induction of adjuvant arthritis and paralleled to a large extent the development of inflammation in both the adjuvant injected (right) hind paw and in the non-injected, contralateral paw. By day 26, the level of free collagenolytic activity in the injected paw had increased to a level 30 times normal while that in the contralateral paw had increased to a level 10 times normal. Treatment of the residues from the injected paws with trypsin resulted in the activation of a latent collagenolytic activity which, on day 26, accounted for approximately 50% of the total activity. The elevated level of collagen prolyl hydroxylase in the inflamed paw suggested that the rate of collagen synthesis was also increased. The activity of beta-glucuronidase increased in the inflamed paw with time after the induction of adjuvant arthritis while that of cathepsin G was elevated as compared to normal in paws removed, 5 but not 22 days after the induction of adjuvant arthritis. The inflamed paw of the adjuvant rat may represent a useful system in which to study the role of collagenolytic enzymes in the destruction of connective tissue by inflammatory lesions. | lld:pubmed |
| pubmed-article:6271251 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6271251 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6271251 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6271251 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6271251 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:6271251 | pubmed:author | pubmed-author:SalvadorR ARA | lld:pubmed |
| pubmed-article:6271251 | pubmed:author | pubmed-author:CoffeyJ WJW | lld:pubmed |
| pubmed-article:6271251 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6271251 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:6271251 | pubmed:volume | 677 | lld:pubmed |
| pubmed-article:6271251 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6271251 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6271251 | pubmed:pagination | 243-52 | lld:pubmed |
| pubmed-article:6271251 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:meshHeading | pubmed-meshheading:6271251-... | lld:pubmed |
| pubmed-article:6271251 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6271251 | pubmed:articleTitle | Levels of collagenolytic activity, beta-glucuronidase, and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis. | lld:pubmed |
| pubmed-article:6271251 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6271251 | pubmed:publicationType | Comparative Study | lld:pubmed |
