| pubmed-article:6266257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6266257 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6266257 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:6266257 | lifeskim:mentions | umls-concept:C0029442 | lld:lifeskim |
| pubmed-article:6266257 | lifeskim:mentions | umls-concept:C0006674 | lld:lifeskim |
| pubmed-article:6266257 | lifeskim:mentions | umls-concept:C0008318 | lld:lifeskim |
| pubmed-article:6266257 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6266257 | lifeskim:mentions | umls-concept:C0204695 | lld:lifeskim |
| pubmed-article:6266257 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:6266257 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6266257 | pubmed:dateCreated | 1981-9-15 | lld:pubmed |
| pubmed-article:6266257 | pubmed:abstractText | The objectives of this study were to evaluate the effects of vitamin D(3) (D(3)) and 1,25-dihydroxyvitamin D(3) (1,25-(OH)(2)D(3)) on uremic bone disease independent of their action on the intestine. The histomorphology of tibial metaphyses in uremic (5/6 nephrectomized [5/6 Nx]) rats fed a low-calcium-low-phosphorus (LCLP) diet was compared with sham-operated (SO) rats fed an LCLP diet and 5/6 Nx rats fed an LCLP diet and given 15,000 IU D(3) or 5 units (135 ng) 1,25-(OH)(2)D(3) daily for 7 days. A marked osteomalacia characterized by an increased percentage of active and inactive trabecular osteoid surface and thickened growth plates developed in proximal tibial metaphyses in 5/6 Nx rats given the placebo, compared with SO rats. These bone changes were associated with relative hypophosphatemia, hypophosphaturia, and hypercalciuria in 5/6 Nx rats. In 5/6 Nx rats treated with D(3) or 1,25-(OH)(2)D(3) the growth plates had undergone mineralization and vascular invasion and were markedly reduced in thickness. Other parameters of osteomalacia in trabecular bone were not different from 5/6 Nx rats given the placebo. There was a significant decrease in osteoclasts per millimeter of trabecular surface perimeter in D(3)- and 1,25-(OH)(2)D(3)-treated rats. These bone changes were associated with hypercalcemia, hyperphosphatemia, and hyperphosphaturia, compared with 5/6 Nx rats given the placebo. It was concluded that in uremic rats fed the LCLP diet, shortterm treatment with either pharmacologic levels of D(3) or 1,25-(OH)(2)D(3) corrected only lesions in the growth plate. Osteoid seams were not reduced in treated rats, although the serum calcium-phosphorus product was elevated. The 5/6 Nx rat fed the LCLP diet appears to be a useful model for the rapid induction of uremic osteomalacia in adult animals. | lld:pubmed |
| pubmed-article:6266257 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6266257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6266257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6266257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6266257 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6266257 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:6266257 | pubmed:author | pubmed-author:WeisbrodeS... | lld:pubmed |
| pubmed-article:6266257 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6266257 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:6266257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6266257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6266257 | pubmed:pagination | 35-40 | lld:pubmed |
| pubmed-article:6266257 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:meshHeading | pubmed-meshheading:6266257-... | lld:pubmed |
| pubmed-article:6266257 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6266257 | pubmed:articleTitle | Short-term effects of vitamin D3 and 1,25-dihydroxyvitamin D3 on osteomalacia in uremic rats fed a low calcium-low-phosphorus diet. | lld:pubmed |
| pubmed-article:6266257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6266257 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
