pubmed-article:6253663 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:6253663 | lifeskim:mentions | umls-concept:C0000742 | lld:lifeskim |
pubmed-article:6253663 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
pubmed-article:6253663 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
pubmed-article:6253663 | lifeskim:mentions | umls-concept:C1150527 | lld:lifeskim |
pubmed-article:6253663 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:6253663 | pubmed:dateCreated | 1981-1-16 | lld:pubmed |
pubmed-article:6253663 | pubmed:abstractText | Several transformation-defective (td) mutants of Abelson murine leukemia virus (AbLV) are described. Cells nonproductively infected with such mutants exhibited a high degree of growth contact inhibition, failed to form colonies in soft agar, lacked rescuable transforming virus, and were as susceptible as uninfected control cells to transformation by wild-type (wt) AbLV pseudotype virus. In addition, each of several td AbLV nonproductively infected cell clones analyzed was found to be nontumorigenic in vivo. Biochemical analysis of td mutant AbLV-infected clones revealed levels of expression of the major AbLV translational product, P120, and a highly related 80,000-Mr AbLV-encoded protein, P80, at concentrations analogous to those in wt AbLV-transformed cells. Although the AbLV-specific 120,000-Mr polyproteins expressed in td mutant AbLV-infected clones were indistinguishable from those in wt AbLV-transformed lines with respect to molecular weight and [35S]methionine tryptic peptide composition, they each differed from wt AbLV P120 in their patterns of post-translational phosphorylation. A previously described AbLV-associated protein kinase activity is shown to recognize as substrate a major tyrosine-specific acceptor site(s) contained within a single well-resolved tryptic peptide common to both AbLV P120 and P80. In vitro [gamma-32P]ATP-mediated labeling of this phosphorylation site was reduced to below detectable levels in td mutant nonproductively infected cell clones. These findings establish that the AbLV-encoded polyprotein P120 and its associated protein kinase activity are involved in AbLV tumorigenesis. | lld:pubmed |
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pubmed-article:6253663 | pubmed:language | eng | lld:pubmed |
pubmed-article:6253663 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:6253663 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:6253663 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:6253663 | pubmed:month | Nov | lld:pubmed |
pubmed-article:6253663 | pubmed:issn | 0022-538X | lld:pubmed |
pubmed-article:6253663 | pubmed:author | pubmed-author:StephensonJ... | lld:pubmed |
pubmed-article:6253663 | pubmed:author | pubmed-author:ReynoldsF... | lld:pubmed |
pubmed-article:6253663 | pubmed:author | pubmed-author:Van de VenW... | lld:pubmed |
pubmed-article:6253663 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:6253663 | pubmed:volume | 36 | lld:pubmed |
pubmed-article:6253663 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:6253663 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:6253663 | pubmed:pagination | 374-86 | lld:pubmed |
pubmed-article:6253663 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:6253663 | pubmed:year | 1980 | lld:pubmed |
pubmed-article:6253663 | pubmed:articleTitle | Abelson murine leukemia virus transformation-defective mutants with impaired P120-associated protein kinase activity. | lld:pubmed |
pubmed-article:6253663 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:6253663 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:6253663 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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