| pubmed-article:6251478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6251478 | lifeskim:mentions | umls-concept:C0026626 | lld:lifeskim |
| pubmed-article:6251478 | lifeskim:mentions | umls-concept:C0025918 | lld:lifeskim |
| pubmed-article:6251478 | lifeskim:mentions | umls-concept:C0598766 | lld:lifeskim |
| pubmed-article:6251478 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:6251478 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:6251478 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6251478 | pubmed:dateCreated | 1980-11-25 | lld:pubmed |
| pubmed-article:6251478 | pubmed:abstractText | Intrathymic injection of SMX-1, a dualtropic murine leukemia virus (MuLV) originally derived from Moloney murine leukemia virus stocks, protects AKR mice from developing MuLV-accelerated leukemia and spontaneous leukemia. Thymuses of SMX-1-injected mice show no change in weight, morphology, or thymocyte size, and quantitative expression of Thy-1 and Lyt-2 differentiation antigens is identical to control mice. The amplified thymic expression of MuLV-related antigens that occurs spontaneously in 6-month-old preleukemic AKR mice or that can be induced in young AKR mice by leukemogenic AKR dualtropic MuLV is prevented by SMX-1. It appears unlikely that the protective effect of SMX-1 is explicable in terms of cross-immunogenicity with transforming MuLV or transformed cells. As SMX-1 persists for long periods after intrathymic injection and does not alter levels of thymic ecotropic MuLV, SMX-1 may interfere with the generation, spread, or leukemogenicity of dualtropic MuLV that form de novo in AKR thymus during the late preleukemic phase. SMX-1 provides a way to probe the events leading to cell transformation in AKR mice. | lld:pubmed |
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| pubmed-article:6251478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6251478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6251478 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6251478 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6251478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6251478 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:6251478 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6251478 | pubmed:author | pubmed-author:StockertEE | lld:pubmed |
| pubmed-article:6251478 | pubmed:author | pubmed-author:ObataYY | lld:pubmed |
| pubmed-article:6251478 | pubmed:author | pubmed-author:OldL JLJ | lld:pubmed |
| pubmed-article:6251478 | pubmed:author | pubmed-author:O'DonnellP... | lld:pubmed |
| pubmed-article:6251478 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6251478 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:6251478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6251478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6251478 | pubmed:pagination | 3720-4 | lld:pubmed |
| pubmed-article:6251478 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6251478 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6251478 | pubmed:articleTitle | Inhibition of AKR leukemogenesis by SMX-1, a dualtropic murine leukemia virus. | lld:pubmed |
| pubmed-article:6251478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6251478 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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