| pubmed-article:6250713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6250713 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:6250713 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:6250713 | lifeskim:mentions | umls-concept:C0017287 | lld:lifeskim |
| pubmed-article:6250713 | lifeskim:mentions | umls-concept:C0012868 | lld:lifeskim |
| pubmed-article:6250713 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6250713 | pubmed:dateCreated | 1980-11-24 | lld:pubmed |
| pubmed-article:6250713 | pubmed:abstractText | The his4-912 mutation results from insertion of a 6200 bp transposable element into the his4 gene of yeast. In order to clone the his4-912 mutation, the plasmid pBR322 was integrated into the his4 gene by means of yeast transformation, and then the vector sequences and the his4-912 insertion element were excised as a single restriction fragment. This his 4-912 insertion element is homologous to Ty1, a family of repetitive yeast DNA sequences. His+ revertants derived from the his4-912 mutant carry a number of chromosomal aberrations including deletions, translocations, a transposition and an inversion. The majority of His+ revertants result from deletions which have both endpoints within the element and which leave behind only 300 bp of the insertion element. Other derivatives of the his4-912 mutant carry deletions which have one endpoint in the insertion element and one endpoint in the his4 coding sequence. In two His+ revertants carrying reciprocal translocations, the chromosome III translocation breakpoints occur within the his4-912 insertion element. A His+ revertant carrying an inversion of most of the left arm of chromosome III may be an intermediate in transposition of the his4-912 insertion element to a new site on chromosome III. | lld:pubmed |
| pubmed-article:6250713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6250713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6250713 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6250713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6250713 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6250713 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:6250713 | pubmed:author | pubmed-author:FinkG RGR | lld:pubmed |
| pubmed-article:6250713 | pubmed:author | pubmed-author:RoederG SGS | lld:pubmed |
| pubmed-article:6250713 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6250713 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:6250713 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6250713 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6250713 | pubmed:pagination | 239-49 | lld:pubmed |
| pubmed-article:6250713 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:6250713 | pubmed:meshHeading | pubmed-meshheading:6250713-... | lld:pubmed |
| pubmed-article:6250713 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6250713 | pubmed:articleTitle | DNA rearrangements associated with a transposable element in yeast. | lld:pubmed |
| pubmed-article:6250713 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6250713 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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