| pubmed-article:6246490 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6246490 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:6246490 | lifeskim:mentions | umls-concept:C0004114 | lld:lifeskim |
| pubmed-article:6246490 | lifeskim:mentions | umls-concept:C0034403 | lld:lifeskim |
| pubmed-article:6246490 | lifeskim:mentions | umls-concept:C0178702 | lld:lifeskim |
| pubmed-article:6246490 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:6246490 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6246490 | pubmed:dateCreated | 1980-7-22 | lld:pubmed |
| pubmed-article:6246490 | pubmed:abstractText | C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent challenge by l-isoproterenol (desensitization). This loss in responsiveness is paralleled by a 20-30% decrease in the apparent number of beta-adrenergic receptors and by increased release of arachidonic aciid into the medium. The increased release of arachidonic acid is caused by the action of phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) and corresponds to increased turnover of methylated phospholipids. Mepacrine and tetracaine, both inhibitors of this phospholipase A2, are able to block l-isoproterenol-induced desensitization of cyclic AMP production and the decrease in beta-adrenergic receptors. Mellitin and phorbol ester, two activators of phospholipase A2, when preincubated with the cells cause a decreased cyclic AMP response of the cells to l-isoproterenol. These results suggest that the activation of phospholipase A2 in the local domain of the beta-adrenergic receptor may be involved in desensitization. | lld:pubmed |
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| pubmed-article:6246490 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6246490 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6246490 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6246490 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6246490 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6246490 | pubmed:author | pubmed-author:HenneberryR... | lld:pubmed |
| pubmed-article:6246490 | pubmed:author | pubmed-author:AxelrodJJ | lld:pubmed |
| pubmed-article:6246490 | pubmed:author | pubmed-author:HirataFF | lld:pubmed |
| pubmed-article:6246490 | pubmed:author | pubmed-author:TallmanJ FJF | lld:pubmed |
| pubmed-article:6246490 | pubmed:author | pubmed-author:MallorgaPP | lld:pubmed |
| pubmed-article:6246490 | pubmed:author | pubmed-author:StrittmatterW... | lld:pubmed |
| pubmed-article:6246490 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6246490 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:6246490 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6246490 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6246490 | pubmed:pagination | 1341-5 | lld:pubmed |
| pubmed-article:6246490 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6246490 | pubmed:meshHeading | pubmed-meshheading:6246490-... | lld:pubmed |
| pubmed-article:6246490 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6246490 | pubmed:articleTitle | Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells. | lld:pubmed |
| pubmed-article:6246490 | pubmed:publicationType | Journal Article | lld:pubmed |
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