| pubmed-article:6234351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0024297 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0080202 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0035015 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0042382 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C1882923 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C1548437 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C1521721 | lld:lifeskim |
| pubmed-article:6234351 | lifeskim:mentions | umls-concept:C0522536 | lld:lifeskim |
| pubmed-article:6234351 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:6234351 | pubmed:dateCreated | 1984-8-20 | lld:pubmed |
| pubmed-article:6234351 | pubmed:abstractText | A series of adoptive transfer studies were performed to define both the role of lymphocyte subpopulations and of lymphokines in the reestablishment of immunologic responsiveness towards vascularized organ allografts in T cell-deprived B rats. Acute rejection of otherwise indefinitely surviving cardiac allografts (10.9 +/- 2.9 days) occurred when sensitized T cells were adoptively transferred with a course of partially purified, lectin-free IL 2-conditioned medium (IL 2CM), whereas rats receiving T cells alone rejected their grafts at 19.8 +/- 4.6 days (p = 0.025). Rejection is mediated primarily by alloactivated T helper cells highly enriched for W3/25 phenotype. The relationship between the mean allograft survival time and the cell number transferred was of exponential order. In contrast to rejection occurring after the transfer of intact T cells, that produced by W3/25+ cells was independent of the administration of exogenous IL 2CM. W3/25+ T helper cells were also found to be less potent in mediating graft rejection than were whole T cells when limited cell numbers were transferred. The OX8+ T cytotoxic/suppressor cell subpopulation, even when supplied with a course of IL 2CM, was unable to bring about rejection, but induced transient graft enlargement in about 50% of the animals. Recombination of individual subsets caused acute rejection at a rate comparable to that of unseparated T cells when IL 2CM was supplied (10.8 +/- 1.0 days), in contrast to those rats which received the recombined inoculum in the absence of IL 2CM (16.8 +/- 2.2 days, p = 0.025). Lymphocyte migration studies revealed a more vigorous homing of OX8+ cells to the allograft as compared to W3/25+ cells. However, to produce maximal accumulation of transferred cells in the graft, both T cell subsets supplemented by lymphokines must be introduced together into T cell-deprived hosts. | lld:pubmed |
| pubmed-article:6234351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6234351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6234351 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6234351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6234351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6234351 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6234351 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6234351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6234351 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6234351 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6234351 | pubmed:author | pubmed-author:TilneyN LNL | lld:pubmed |
| pubmed-article:6234351 | pubmed:author | pubmed-author:StromT BTB | lld:pubmed |
| pubmed-article:6234351 | pubmed:author | pubmed-author:Kupiec-Weglin... | lld:pubmed |
| pubmed-article:6234351 | pubmed:author | pubmed-author:AranedaDD | lld:pubmed |
| pubmed-article:6234351 | pubmed:author | pubmed-author:LearP APA | lld:pubmed |
| pubmed-article:6234351 | pubmed:author | pubmed-author:Abbud-FilhoMM | lld:pubmed |
| pubmed-article:6234351 | pubmed:author | pubmed-author:HeideckeC DCD | lld:pubmed |
| pubmed-article:6234351 | pubmed:author | pubmed-author:AraujoJ LJL | lld:pubmed |
| pubmed-article:6234351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6234351 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:6234351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6234351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6234351 | pubmed:pagination | 582-8 | lld:pubmed |
| pubmed-article:6234351 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6234351 | pubmed:meshHeading | pubmed-meshheading:6234351-... | lld:pubmed |
| pubmed-article:6234351 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6234351 | pubmed:articleTitle | Interactions between T lymphocyte subsets supported by interleukin 2-rich lymphokines produce acute rejection of vascularized cardiac allografts in T cell deprived rats. | lld:pubmed |
| pubmed-article:6234351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6234351 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6234351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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