| pubmed-article:6230414 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C0031272 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C0020835 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C0021017 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:6230414 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:6230414 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6230414 | pubmed:dateCreated | 1984-4-4 | lld:pubmed |
| pubmed-article:6230414 | pubmed:abstractText | The nature of the IgA B cell precursors that receive preferential help from selected clones of T helper cells from mouse Peyer's patches (PP Th A) were studied. Activation of the PP Th A clones required the presence of antigen, sheep erythrocytes (SRBC), in a culture system supporting development of antibody-secreting plasma cells. Two types of PP Th A cells were used. Both gave vigorous IgA responses; the first also supported low IgM, and the second low IgM and IgG subclass antibody responses. Removal of sIgA+ B cells from either splenic or PP B cell cultures selectively depleted precursors of IgA antibody producers. Cultures of purified sIgA+ B cells, cloned PP Th A cells and SRBC, selectively yielded IgA antibody producers. Finally, PP Th A cells did not support IgA responses in B cell cultures derived from spleens of young mice (days 1-25), and full IgA responses were not seen until the donor mice were 6-7 wk of age. These results suggest that cloned T helper cells can recognize and collaborate with mature, IgA committed B cells. | lld:pubmed |
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| pubmed-article:6230414 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6230414 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6230414 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6230414 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6230414 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6230414 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:6230414 | pubmed:author | pubmed-author:CooperM DMD | lld:pubmed |
| pubmed-article:6230414 | pubmed:author | pubmed-author:KearneyJ FJF | lld:pubmed |
| pubmed-article:6230414 | pubmed:author | pubmed-author:KoopmanW JWJ | lld:pubmed |
| pubmed-article:6230414 | pubmed:author | pubmed-author:McGheeJ RJR | lld:pubmed |
| pubmed-article:6230414 | pubmed:author | pubmed-author:MichalekS MSM | lld:pubmed |
| pubmed-article:6230414 | pubmed:author | pubmed-author:KiyonoHH | lld:pubmed |
| pubmed-article:6230414 | pubmed:author | pubmed-author:MostellerL... | lld:pubmed |
| pubmed-article:6230414 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6230414 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:6230414 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:6230414 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6230414 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6230414 | pubmed:pagination | 798-811 | lld:pubmed |
| pubmed-article:6230414 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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