Linked Life Data

621673

Source:http://linkedlifedata.com/resource/pubmed/id/621673

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:621673rdf:typepubmed:Citationlld:pubmed
pubmed-article:621673lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C0032043lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C0001041lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C0008508lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C1285052lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C0205409lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C0030685lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C1948027lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C0680255lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C0391871lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C1283071lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C1963578lld:lifeskim
pubmed-article:621673lifeskim:mentionsumls-concept:C0684164lld:lifeskim
pubmed-article:621673pubmed:issue2lld:pubmed
pubmed-article:621673pubmed:dateCreated1978-3-29lld:pubmed
pubmed-article:621673pubmed:abstractTextIsolated villus from human term placenta contains about 167 nmol/g of acetylcholine (ACh). It was incubated in a muscle bath containing Krebs-Ringer bicarbonate buffer (pH 7.2-7.4) at 37 degrees C and ACh released into the medium was analyzed by pyrolysis-gas chromatography. The spontaneous release of ACh into the medium was linear with time and was 35 pmol/g/min. ACh was not released when Ca++ was absent in the medium. Raising the Ca++ concentration in the Krebs-Ringer bicarbonate buffer from 2.34 to 4.64 mM, or adding L-nicotine (58 muM) to the bath, increased the rate of release of ACh to 53 and 47 pmol/min respectively. Nicotine did not exhibit any effect on ACh release in the absence of Ca++ in the medium. Both the rate of the spontaneous release of ACh and the nicotine-induced increase in the release of ACh was decreased by atropine (152 muM). They were not influenced by d-tubocurarine (30 muM). Depolarizing concentrations of potassium (16-63 mM) in the medium increased the rate of release of ACh. Cocaine, a known Ca antagonist, decreased the rate of spontaneous release of ACh as well as nicotine-induced release of ACh. These observations indicate that 1) Ca++ ions in the external medium are required for release of ACh, 2) Ca++ ions in the external medium are required for release of ACh, 2) Ca++ ions act as a link between the stimulation of ACh release and the final release of ACh and 3) The effect of nicotine on placental release of ACh may be classified as a muscarinic type.lld:pubmed
pubmed-article:621673pubmed:languageenglld:pubmed
pubmed-article:621673pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:citationSubsetIMlld:pubmed
pubmed-article:621673pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:621673pubmed:statusMEDLINElld:pubmed
pubmed-article:621673pubmed:monthFeblld:pubmed
pubmed-article:621673pubmed:issn0022-3565lld:pubmed
pubmed-article:621673pubmed:authorpubmed-author:Rama...lld:pubmed
pubmed-article:621673pubmed:authorpubmed-author:OlubadewoJ...lld:pubmed
pubmed-article:621673pubmed:issnTypePrintlld:pubmed
pubmed-article:621673pubmed:volume204lld:pubmed
pubmed-article:621673pubmed:ownerNLMlld:pubmed
pubmed-article:621673pubmed:authorsCompleteYlld:pubmed
pubmed-article:621673pubmed:pagination433-45lld:pubmed
pubmed-article:621673pubmed:dateRevised2006-11-15lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-H...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-P...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-P...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-A...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-C...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-M...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-A...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-N...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-P...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-B...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-F...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-T...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-C...lld:pubmed
pubmed-article:621673pubmed:meshHeadingpubmed-meshheading:621673-D...lld:pubmed
pubmed-article:621673pubmed:year1978lld:pubmed
pubmed-article:621673pubmed:articleTitleHuman placental cholinergic system: stimulation-secretion coupling for release of acetylcholine from isolated placental villus.lld:pubmed
pubmed-article:621673pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:621673pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:621673pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:621673lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:621673lld:pubmed