| pubmed-article:6207913 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6207913 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:6207913 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6207913 | lifeskim:mentions | umls-concept:C1517806 | lld:lifeskim |
| pubmed-article:6207913 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6207913 | lifeskim:mentions | umls-concept:C0049065 | lld:lifeskim |
| pubmed-article:6207913 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:6207913 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:6207913 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:6207913 | pubmed:dateCreated | 1984-11-28 | lld:pubmed |
| pubmed-article:6207913 | pubmed:abstractText | The alpha-D-anomer of 5-aza-2'-deoxycytidine inhibited cell growth in vitro in L1210 mouse leukemic cells (concentration causing 50% inhibition about 1 X 10(-6) M) and was also active in vivo in increasing the life span of mice with L1210 leukemia by 100% after a single i.p. injection (800 to 1000 mg/kg). This effect could be reversed by 2'-deoxycytidine. The alpha-D-anomer produced approximately 100-fold less host toxicity than did 5-aza-2'-deoxycytidine. It was observed that alpha-D-anomer, when kept at 23 degrees for 72 hr, inhibited the uptake of radioactive 2'-deoxycytidine by L1210 cells in vitro as well as the phosphorylation of 2'-deoxycytidine by a cell-free extract from L1210 cells. These effects could not be obtained with the fresh solution of the drug. It is proposed that the action of alpha-D-anomer is due to its conversion to 5-aza-2'-deoxycytidine as shown by high-performance liquid chromatography performed on water solutions of both anomers. | lld:pubmed |
| pubmed-article:6207913 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6207913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6207913 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6207913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6207913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6207913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6207913 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6207913 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6207913 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:6207913 | pubmed:author | pubmed-author:VeselýJJ | lld:pubmed |
| pubmed-article:6207913 | pubmed:author | pubmed-author:PískalaAA | lld:pubmed |
| pubmed-article:6207913 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6207913 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:6207913 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6207913 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6207913 | pubmed:pagination | 5165-8 | lld:pubmed |
| pubmed-article:6207913 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:meshHeading | pubmed-meshheading:6207913-... | lld:pubmed |
| pubmed-article:6207913 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6207913 | pubmed:articleTitle | Effects of the alpha-D-anomer of 5-aza-2'-deoxycytidine on L1210 mouse leukemic cells in vitro and in vivo. | lld:pubmed |
| pubmed-article:6207913 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6207913 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
