| pubmed-article:6206498 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6206498 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6206498 | lifeskim:mentions | umls-concept:C0015980 | lld:lifeskim |
| pubmed-article:6206498 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:6206498 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:6206498 | lifeskim:mentions | umls-concept:C0008664 | lld:lifeskim |
| pubmed-article:6206498 | lifeskim:mentions | umls-concept:C0008643 | lld:lifeskim |
| pubmed-article:6206498 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:6206498 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:6206498 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:6206498 | pubmed:dateCreated | 1984-10-24 | lld:pubmed |
| pubmed-article:6206498 | pubmed:abstractText | We examined the proposed role of human chromosome 21 in determining the cellular sensitivity to human alpha, beta, and gamma interferons (HuIFN-alpha, -beta, and -gamma) and the expression of the receptors for the HuIFNs with the use of mouse-human hybrid cells containing human chromosome 21. Hybrid cells (WA17) containing three copies of human chromosome 21 showed specific displaceable binding of 125I-labeled HuIFN-alpha 2 (125I-HuIFN-alpha 2), which was not observed with mouse parent (A9) cells. Crosslinking of 125I-HuIFN-alpha 2 bound to WA17 cells with disuccinimidyl suberate yielded a complex of Mr approximately equal to 150,000 similar to the 125I-HuIFN-alpha 2-receptor complex obtained with human cells as described earlier. Such a complex was not obtained with mouse parent (A9) cells or with hybrid cells containing certain other human chromosomes but not chromosome 21. Mice inoculated with mouse-human hybrid cells containing human chromosome 21 produce antibodies that block the antiviral action of HuIFN-alpha and -beta on human cells. Such antibodies could immunoprecipitate the 125I-HuIFN-alpha 2-receptor complex obtained from human cells but not free 125I-HuIFN-alpha 2, indicating that these antibodies were directed against the receptor. WA17 hybrid cells were highly sensitive to the antiviral action of HuIFN-alpha 2, -alpha (Le) and -beta but were completely insensitive to HuIFN-gamma. Furthermore, 125I-HuIFN-gamma showed specific binding to human WISH cells but not to WA17 hybrid cells or A9 mouse cells. The results indicate that the receptors for HuIFN-alpha and -beta but not for HuIFN-gamma are specified by human chromosome 21. Hybrid cells containing one, two, or three copies of human chromosome 21 were found to be increasingly sensitive to HuIFN-alpha 2, indicating that a chromosome 21-specified component (possibly the HuIFN-alpha receptor) may be a limiting factor in the cellular sensitivity to HuIFN-alpha. | lld:pubmed |
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| pubmed-article:6206498 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6206498 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6206498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6206498 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:6206498 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6206498 | pubmed:author | pubmed-author:RuddleF HFH | lld:pubmed |
| pubmed-article:6206498 | pubmed:author | pubmed-author:GuptaS LSL | lld:pubmed |
| pubmed-article:6206498 | pubmed:author | pubmed-author:ShulmanLL | lld:pubmed |
| pubmed-article:6206498 | pubmed:author | pubmed-author:SarkarF HFH | lld:pubmed |
| pubmed-article:6206498 | pubmed:author | pubmed-author:RaziuddinAA | lld:pubmed |
| pubmed-article:6206498 | pubmed:author | pubmed-author:DutkowskiRR | lld:pubmed |
| pubmed-article:6206498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6206498 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:6206498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6206498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6206498 | pubmed:pagination | 5504-8 | lld:pubmed |
| pubmed-article:6206498 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6206498 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6206498 | pubmed:articleTitle | Receptors for human alpha and beta interferon but not for gamma interferon are specified by human chromosome 21. | lld:pubmed |
| pubmed-article:6206498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6206498 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6206498 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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