| pubmed-article:6204777 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C0237868 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C0036679 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C0023509 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:6204777 | lifeskim:mentions | umls-concept:C2348628 | lld:lifeskim |
| pubmed-article:6204777 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6204777 | pubmed:dateCreated | 1984-9-6 | lld:pubmed |
| pubmed-article:6204777 | pubmed:abstractText | These experiments were designed to determine if separate subpopulations of T cells were involved in the syngeneic and allogeneic mixed lymphocyte reaction. Rat lymph node T cells were separated into W3/25+ and W3/25- subpopulations by panning with the monoclonal antibody W3/25 and tested for their ability to proliferate in both syngeneic (SMLR) and allogeneic (MLR) mixed lymphocyte responses, as well as to develop cytotoxicity against allogeneic, syngeneic, and trinitrophenol (TNP)-modified syngeneic targets. The W3/25+ T cells reacted strongly in the SMLR and the MLR whereas the W3/25- fraction proliferated only in response to allogeneic stimulation and with a kinetic pattern distinct from W3/25+. Furthermore, addition of W3/25 monoclonal antibody directly to the cultures was shown only to inhibit the proliferation of the W3/25+ T-cell fraction. The W3/25- subpopulation contained cytotoxic T cells (CTLs) against both allogeneic determinants and TNP-modified self. However the requirements for the activation of allospecific CTLs were distinct from those for CTLs for TNP-self in that W3/25- allospecific CTLs required no detectable help from W3/25+ T cells but generation of the CTL response against TNP-self required the presence of W3/25+ helper T cells (Th). These data suggest that in the rat, there exist subsets of T cells recognized by their cell surface phenotype that distinguish between self and nonself determinants and the requirements for activation are different for each of these populations. | lld:pubmed |
| pubmed-article:6204777 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6204777 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6204777 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6204777 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6204777 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6204777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6204777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6204777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6204777 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6204777 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6204777 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:6204777 | pubmed:issn | 0008-8749 | lld:pubmed |
| pubmed-article:6204777 | pubmed:author | pubmed-author:KaplanA MAM | lld:pubmed |
| pubmed-article:6204777 | pubmed:author | pubmed-author:SoporiM LML | lld:pubmed |
| pubmed-article:6204777 | pubmed:author | pubmed-author:RoszmanT LTL | lld:pubmed |
| pubmed-article:6204777 | pubmed:author | pubmed-author:CherianSS | lld:pubmed |
| pubmed-article:6204777 | pubmed:author | pubmed-author:CowanW AWA | lld:pubmed |
| pubmed-article:6204777 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6204777 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:6204777 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6204777 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6204777 | pubmed:pagination | 295-303 | lld:pubmed |
| pubmed-article:6204777 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6204777 | pubmed:meshHeading | pubmed-meshheading:6204777-... | lld:pubmed |
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| pubmed-article:6204777 | pubmed:meshHeading | pubmed-meshheading:6204777-... | lld:pubmed |
| pubmed-article:6204777 | pubmed:meshHeading | pubmed-meshheading:6204777-... | lld:pubmed |
| pubmed-article:6204777 | pubmed:meshHeading | pubmed-meshheading:6204777-... | lld:pubmed |
| pubmed-article:6204777 | pubmed:meshHeading | pubmed-meshheading:6204777-... | lld:pubmed |
| pubmed-article:6204777 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6204777 | pubmed:articleTitle | T-lymphocyte heterogeneity in the rat: separation of distinct rat T-lymphocyte populations which respond in syngeneic and allogeneic mixed lymphocyte reactions. | lld:pubmed |
| pubmed-article:6204777 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6204777 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6204777 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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