| pubmed-article:6203214 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6203214 | lifeskim:mentions | umls-concept:C1000205 | lld:lifeskim |
| pubmed-article:6203214 | lifeskim:mentions | umls-concept:C0332466 | lld:lifeskim |
| pubmed-article:6203214 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:6203214 | lifeskim:mentions | umls-concept:C1513380 | lld:lifeskim |
| pubmed-article:6203214 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:6203214 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6203214 | pubmed:dateCreated | 1984-7-11 | lld:pubmed |
| pubmed-article:6203214 | pubmed:abstractText | The FBR murine osteosarcoma virus complex induces bone tumors with a similar latency and pathology to those induced by the FBJ virus complex. FBR murine sarcoma virus ( FBR -MSV) has been isolated from its helper virus(es) by the establishment of transformed nonproducer cells. These cells were found to express a 75,000-Da protein (P75) which was antigenically related to the p55 oncogene product of the FBJ murine osteosarcoma virus ( FBJ -MSV). P75 also contained antigenic determinants of murine leukemia virus (MLV) gag gene p15, p12, and p30 proteins, and is therefore a gag- fos fusion protein ( P75gag - fos ). P75gag - fos is a phosphoprotein and is found primarily in the nucleus. Only a single species of RNA, of 3.3 kb, was identified in FBR -MSV-transformed nonproducer cells using both fos and MLV probes, which suggested that P75gag - fos was expressed from genome-sized RNA. Chromosomal DNA from one nonproducer cell line was found to contain a single EcoRI restriction fragment of 12 kb pairs (kbp) which encompassed the FBR -MSV provirus. This DNA fragment was molecularly cloned into bacteriophage Charon 30 (lambda FBR -1), and a 7.5-kbp HindIII restriction fragment containing the entire provirus was subsequently subcloned into pBR322 ( pFBR -1). DNA from pFBR -1 was capable of inducing morphological transformation of mouse and rat fibroblasts in tissue culture. In addition, transfected cells expressed the FBR -MSV P75gag - fos protein. | lld:pubmed |
| pubmed-article:6203214 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6203214 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6203214 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6203214 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6203214 | pubmed:month | May | lld:pubmed |
| pubmed-article:6203214 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:6203214 | pubmed:author | pubmed-author:VermaI MIM | lld:pubmed |
| pubmed-article:6203214 | pubmed:author | pubmed-author:CurranTT | lld:pubmed |
| pubmed-article:6203214 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6203214 | pubmed:volume | 135 | lld:pubmed |
| pubmed-article:6203214 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6203214 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6203214 | pubmed:pagination | 218-28 | lld:pubmed |
| pubmed-article:6203214 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6203214 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6203214 | pubmed:articleTitle | FBR murine osteosarcoma virus. I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product. | lld:pubmed |
| pubmed-article:6203214 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6203214 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6203214 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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