| pubmed-article:6198176 | pubmed:abstractText | Cerebrospinal fluid (CSF) was removed at a constant flow rate of 1 microliter min-1 from the third ventricle of rats and directly analyzed by liquid chromatography coupled with electrochemical detection. The effect of alphamethyldopa (alpha MD) on CSF alpha MD, dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindolacetic acid (5-HIAA) concentrations was studied for 5 h. alpha MD ethyl ester administration resulted in higher alpha MD levels in CSF as compared with alpha MD administration, suggesting a higher bioavailability of the ethyl ester vs the free acid. A specific inhibition of dopamine metabolism was reflected by a reduction in DOPAC levels while 5-HIAA concentrations were unchanged. | lld:pubmed |
