| pubmed-article:6196783 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6196783 | lifeskim:mentions | umls-concept:C0302606 | lld:lifeskim |
| pubmed-article:6196783 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:6196783 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:6196783 | lifeskim:mentions | umls-concept:C0035700 | lld:lifeskim |
| pubmed-article:6196783 | lifeskim:mentions | umls-concept:C0162775 | lld:lifeskim |
| pubmed-article:6196783 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:6196783 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:6196783 | pubmed:dateCreated | 1984-1-27 | lld:pubmed |
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| pubmed-article:6196783 | pubmed:abstractText | Previous findings in our laboratory have identified a specific small nuclear RNA (7S-K) that promotes transcription initiation by RNA polymerase II in isolated mammalian nuclei. The present study was designed to investigate the homology between 7S-K RNAs and host and viral sequences in simian virus 40 (SV40)-transformed and in untransformed mouse 3T3 cells, with the object of testing the hypothesis that these RNAs take part in the transcription initiation complex by base pairing to promoter/enhancer regions of active genes. DNA . RNA hybridization experiments, using either Southern or RNA blotting techniques, indicated that both 7S-K and 7S-L RNAs hybridize to midrepetitive fractions of the mouse genome. However, only 7S-K RNA from transformed cells hybridized to SV40 DNA. Restriction mapping and nuclease S1 treatment of the hybridized region of SV40 yielded a 45-nucleotide-long hybrid duplex. Partial sequence analysis of the 5' end of the DNA in this duplex revealed sequence homology with the 21-base-pair repeat sequence, identified as the SV40 early promoter. Because the viral early gene is expressed in transformed cells, we conclude that 7S-K RNAs in these cells contain a species that has sequence homology to a promoter of an active gene. Taking these results together with previous ones, we postulate that the observed stimulatory activity of 7S-K RNA on transcription initiation is due to its recognition of promoter sequences, either to facilitate the formation or as part of the transcription initiation complex. | lld:pubmed |
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| pubmed-article:6196783 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6196783 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6196783 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6196783 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6196783 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:6196783 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6196783 | pubmed:author | pubmed-author:SohnUU | lld:pubmed |
| pubmed-article:6196783 | pubmed:author | pubmed-author:KrauseMM | lld:pubmed |
| pubmed-article:6196783 | pubmed:author | pubmed-author:SzyszkoJJ | lld:pubmed |
| pubmed-article:6196783 | pubmed:author | pubmed-author:CoombeRR | lld:pubmed |
| pubmed-article:6196783 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6196783 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:6196783 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6196783 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6196783 | pubmed:pagination | 7090-4 | lld:pubmed |
| pubmed-article:6196783 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:6196783 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6196783 | pubmed:articleTitle | 7S-K nuclear RNA from simian virus 40-transformed cells has sequence homology to the viral early promoter. | lld:pubmed |
| pubmed-article:6196783 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6196783 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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