| pubmed-article:6186615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C0678128 | lld:lifeskim |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C1720154 | lld:lifeskim |
| pubmed-article:6186615 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:6186615 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:6186615 | pubmed:dateCreated | 1983-4-7 | lld:pubmed |
| pubmed-article:6186615 | pubmed:abstractText | We have attempted to determine what host mechanisms are responsible for inducing a rapid decrease in the number of Friend leukemia cells (FLC) in the peritoneal cavity of interferon-treated mice. By injecting radiolabelled FLC, we showed that there was a greater loss of radioactivity from individual interferon-treated mice than from control mice. Thus, it was likely that fewer cells were recovered from the peritoneal cavity of interferon-treated mice because of cell destruction. Treatment of mice with interferon limited to the period preceding tumor-cell inoculation conferred some degree of antitumor activity, although this regimen was far less effective than when interferon treatment was initiated and continued daily after tumor-cell inoculation. We have been unable to transfer any antitumor activity with peritoneal washings containing macrophages and lymphocytes from interferon-treated donor mice to tumor-inoculated recipient mice. Inoculation of silica particles i.p., which destroys macrophage function and may affect NK cell activity, did not abrogate interferon's antitumor activity. We suggest that interferon induces a host-mediated antitumor effect by mechanisms which are not mediated by easily recoverable soluble factors or by cytotoxic cells. The nature of this potent interferon-induced host mechanism remains unknown. | lld:pubmed |
| pubmed-article:6186615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6186615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6186615 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6186615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6186615 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6186615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6186615 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:6186615 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:6186615 | pubmed:author | pubmed-author:GresserII | lld:pubmed |
| pubmed-article:6186615 | pubmed:author | pubmed-author:BelardelliFF | lld:pubmed |
| pubmed-article:6186615 | pubmed:author | pubmed-author:MauryCC | lld:pubmed |
| pubmed-article:6186615 | pubmed:author | pubmed-author:MaunouryM TMT | lld:pubmed |
| pubmed-article:6186615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6186615 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:6186615 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:6186615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6186615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6186615 | pubmed:pagination | 821-5 | lld:pubmed |
| pubmed-article:6186615 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
| pubmed-article:6186615 | pubmed:meshHeading | pubmed-meshheading:6186615-... | lld:pubmed |
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| pubmed-article:6186615 | pubmed:meshHeading | pubmed-meshheading:6186615-... | lld:pubmed |
| pubmed-article:6186615 | pubmed:meshHeading | pubmed-meshheading:6186615-... | lld:pubmed |
| pubmed-article:6186615 | pubmed:meshHeading | pubmed-meshheading:6186615-... | lld:pubmed |
| pubmed-article:6186615 | pubmed:meshHeading | pubmed-meshheading:6186615-... | lld:pubmed |
| pubmed-article:6186615 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6186615 | pubmed:articleTitle | Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. II. Role of host mechanisms. | lld:pubmed |
| pubmed-article:6186615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6186615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6186615 | lld:pubmed |
