| pubmed-article:6181281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0996858 | lld:lifeskim |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0001430 | lld:lifeskim |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0007097 | lld:lifeskim |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0021851 | lld:lifeskim |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0017906 | lld:lifeskim |
| pubmed-article:6181281 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:6181281 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6181281 | pubmed:dateCreated | 1982-12-3 | lld:pubmed |
| pubmed-article:6181281 | pubmed:abstractText | Cancerous lesions and nonneoplastic mucosa of surgically extirpated specimens from 94 patients with colorectal carcinoma (of the right colon, 31 patients; of the left colon, 29 patients; and of the rectum, 34 patients) and endoscopically polypectomized specimens from 18 patients with rectal adenoma were examined with fluorescein isothiocyanate-conjugated or horse-radish peroxidase-conjugated Ulex europaeus agglutinin-I (UEA-I) specific to a certain terminal alpha-L-fucosyl residue in glycoconjugates. Of the 31 patients with right colon cancers, 22 showed positive UEA-I binding in the neoplastic cell apexes, apical luminal borders, and luminal secretions. The adjacent nonneoplastic mucosa of all 31 patients, however, demonstrated positive UEA-I binding in the goblet cell mucus. UEA-I binding was positive for 23 of the 29 left colon cancers and for 28 of the 34 rectal cancers, although UEA-I binding was not revealed in the adjacent nonneoplastic mucosa for most of the cases. Of the 18 rectal adenomas, 12 specimens showed positive UEA-I binding in the apical secretions of their adenoma cells. Marked regional differences of UEA-I binding in the nonneoplastic mucosae indicated that the constituents of glycoprotein with UEA-I binding sites in goblet cell mucus differed significantly between the human right and left large bowels. Positive UEA-I binding in many rectal cancerous and adenomatous lesions suggested that a neoplastic glycoprotein with alpha-L-fucosyl residue was produced or that the terminal carbohydrate structure of glycoprotein present in the nonneoplastic mucosa was altered to bind easily with UEA-I after the neoplastic transformation had occurred. A possible relation of this UEA-I binding to blood group H(O) substance is discussed. | lld:pubmed |
| pubmed-article:6181281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6181281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6181281 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6181281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6181281 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6181281 | pubmed:issn | 0027-8874 | lld:pubmed |
| pubmed-article:6181281 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
| pubmed-article:6181281 | pubmed:author | pubmed-author:TanakaSS | lld:pubmed |
| pubmed-article:6181281 | pubmed:author | pubmed-author:YonezawaSS | lld:pubmed |
| pubmed-article:6181281 | pubmed:author | pubmed-author:SatoEE | lld:pubmed |
| pubmed-article:6181281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6181281 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:6181281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6181281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6181281 | pubmed:pagination | 777-85 | lld:pubmed |
| pubmed-article:6181281 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6181281 | pubmed:meshHeading | pubmed-meshheading:6181281-... | lld:pubmed |
| pubmed-article:6181281 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6181281 | pubmed:articleTitle | Glycoconjugate with Ulex europaeus agglutinin-I-binding sites in normal mucosa, adenoma, and carcinoma of the human large bowel. | lld:pubmed |
| pubmed-article:6181281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6181281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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