| pubmed-article:6180010 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C0021400 | lld:lifeskim |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6180010 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:6180010 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6180010 | pubmed:dateCreated | 1982-10-29 | lld:pubmed |
| pubmed-article:6180010 | pubmed:abstractText | Cloned human T lymphocytes induced with influenza A virus (A/Texas/1/77) and maintained in continuous culture with T cell growth factor were assayed for helper function in the in vitro production of anti-influenza antibody. Helper function mediated by both cloned helper T cells and normal peripheral blood lymphocytes was highly antigen dose-dependent, requiring lower concentrations than that necessary to induce blastogenesis. Optimal help was observed with 1 X 10(2) cloned T cells per culture, whereas excess helper cells inhibited the response. After culture with influenza A virus-induced cloned helper T cells, the antibodies formed were directed against influenza A and not B virus. Furthermore, the cloned helper T cells despite being specific for matrix protein collaborated in the production of predominantly anti-hemagglutinin antibody, suggesting associative recognition of the two discrete antigens. Cellular interactions between cloned helper cells from an HLA-Dw1,3 DR1,3 individual and erythrocyte rosette-negative cells required HLA-Dw1; DR1 compatibility for the production of specific antibody. This was confirmed by using subclones. Finally, it was observed that supernatants of the cloned helper T cells contained functional activity capable of replacing the parent cells in the production of anti-influenza A virus antibody. | lld:pubmed |
| pubmed-article:6180010 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6180010 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6180010 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6180010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6180010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6180010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6180010 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6180010 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6180010 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6180010 | pubmed:author | pubmed-author:WoodsJ HJH | lld:pubmed |
| pubmed-article:6180010 | pubmed:author | pubmed-author:HartzmanR JRJ | lld:pubmed |
| pubmed-article:6180010 | pubmed:author | pubmed-author:LambJ RJR | lld:pubmed |
| pubmed-article:6180010 | pubmed:author | pubmed-author:EckelsD DDD | lld:pubmed |
| pubmed-article:6180010 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6180010 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:6180010 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6180010 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6180010 | pubmed:pagination | 1465-70 | lld:pubmed |
| pubmed-article:6180010 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
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| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:meshHeading | pubmed-meshheading:6180010-... | lld:pubmed |
| pubmed-article:6180010 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6180010 | pubmed:articleTitle | In vitro influenza virus-specific antibody production in man: antigen-specific and HLA-restricted induction of helper activity mediated by cloned human T lymphocytes. | lld:pubmed |
| pubmed-article:6180010 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6180010 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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