| pubmed-article:6178603 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6178603 | lifeskim:mentions | umls-concept:C0021747 | lld:lifeskim |
| pubmed-article:6178603 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:6178603 | lifeskim:mentions | umls-concept:C0086168 | lld:lifeskim |
| pubmed-article:6178603 | lifeskim:mentions | umls-concept:C0024426 | lld:lifeskim |
| pubmed-article:6178603 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:6178603 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6178603 | pubmed:dateCreated | 1982-9-10 | lld:pubmed |
| pubmed-article:6178603 | pubmed:abstractText | Resident peritoneal macrophages (M phi) from untreated mice and inflammatory M phi induced by a sterile irritant were able to exert significant suppressive activity on lymphocyte functions. M phi-mediated suppression was evident in lymphocyte proliferation and in a proliferation-independent lymphocyte response (i.e. lymphokine production). The lymphokine macrophage-activating factor (MAF), which enhances tumoricidal capacity of inflammatory but not of resident M phi in vitro, was ineffective in modulating suppressive activity of both resident and inflammatory M phi. In contrast, a significant effect on M phi-mediated suppression was observed upon treatment with IFN-beta. In fact, suppression of lymphoproliferation and of lymphokine production by either resident or inflammatory M phi was significantly decreased or abolished by IFN-beta. Like MAF, IFN-beta was able to increase M phi cytotoxicity against tumor cells. Such as effect, however, was evident in both resident and inflammatory M phi, thus confirming different M phi activation mechanisms for MAF and IFN-beta. These data indicate that IFN-beta acts mainly on mature M phi, which thus appear as the major M phi type involved in suppression. The contrasting effects of IFN-beta on M phi suppression and on M phi-mediated cytotoxicity strongly suggest a dissociation between the 2 induction mechanisms of suppression and cytotoxicity. The in vivo relevance of these two IFN activities was demonstrated by treating mice with the potent IFN inducer polyinosinic polycytidylic acid (poly(I).poly(C). M phi from poly(I).poly(C)-primed mice simultaneously showed enhanced tumoricidal activity and complete abolishment of suppressive capacity. | lld:pubmed |
| pubmed-article:6178603 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6178603 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6178603 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6178603 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6178603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6178603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6178603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6178603 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6178603 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6178603 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6178603 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:6178603 | pubmed:author | pubmed-author:TagliabueAA | lld:pubmed |
| pubmed-article:6178603 | pubmed:author | pubmed-author:BoraschiDD | lld:pubmed |
| pubmed-article:6178603 | pubmed:author | pubmed-author:SoldateschiDD | lld:pubmed |
| pubmed-article:6178603 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6178603 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:6178603 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6178603 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6178603 | pubmed:pagination | 320-6 | lld:pubmed |
| pubmed-article:6178603 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:meshHeading | pubmed-meshheading:6178603-... | lld:pubmed |
| pubmed-article:6178603 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6178603 | pubmed:articleTitle | Macrophage activation by interferon: dissociation between tumoricidal capacity and suppressive activity. | lld:pubmed |
| pubmed-article:6178603 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6178603 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6178603 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6178603 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6178603 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6178603 | lld:pubmed |
