| pubmed-article:6175743 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6175743 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:6175743 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
| pubmed-article:6175743 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
| pubmed-article:6175743 | lifeskim:mentions | umls-concept:C1179517 | lld:lifeskim |
| pubmed-article:6175743 | lifeskim:mentions | umls-concept:C0007613 | lld:lifeskim |
| pubmed-article:6175743 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:6175743 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:6175743 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:6175743 | pubmed:dateCreated | 1982-6-21 | lld:pubmed |
| pubmed-article:6175743 | pubmed:abstractText | 1. Isolated mouse pancreatic acini were used to investigate the effect of secretagogues on acinar cellular electrolytes and cell pH. The effect of changes in the acid-base status of the incubation medium on acinar cellular electrolytes, cell pH and amylase release were also studied. 2. Carbachol at concentrations of 10(-6) or 10(-5) M was without any effect on the intracellular concentrations of total Na+, Na+ exchangeable with 22Na+, K+ and Cl-, and did not influence cell pH as determined by the DMO method. 3. Changes in pHe achieved by varying the HCO3- concentrations at constant CO2, varying the CO2 concentration at constant HCO3- or by titration of a HCO3-/CO2 free HEPES buffered medium did not influence intracellular electrolyte values. 4. pHi changed linearly with pHe by about 1.2 units/pHe unit change over the pHe range of 7.7--6.5. pHi, however, did not change in response to a change in the CO2 tension when the HCO3- concentration was adjusted to keep pHe at 7.4. 5. Lowering pHe below 7.1 inhibited carbachol and CCK8-stimulated amylase release. By contrast a decrease of pHe to 6.8 was without significant effect on basal and secretagogue increased 45Ca2+ efflux from pancreatic acini. 6. In conclusion the pH sensitivity of amylase release by acinar cells is probably related to changes in pHi. Since Ca2+ mobilization is not affected, the pH sensitive step is probably in the mechanism by which Ca2+ activates the release of zymogen granules contents by exocytosis. | lld:pubmed |
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| pubmed-article:6175743 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6175743 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6175743 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6175743 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6175743 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:6175743 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:6175743 | pubmed:author | pubmed-author:WilliamsJ AJA | lld:pubmed |
| pubmed-article:6175743 | pubmed:author | pubmed-author:PreisslerMM | lld:pubmed |
| pubmed-article:6175743 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6175743 | pubmed:volume | 321 | lld:pubmed |
| pubmed-article:6175743 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6175743 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6175743 | pubmed:pagination | 437-48 | lld:pubmed |
| pubmed-article:6175743 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:6175743 | pubmed:meshHeading | pubmed-meshheading:6175743-... | lld:pubmed |
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| pubmed-article:6175743 | pubmed:meshHeading | pubmed-meshheading:6175743-... | lld:pubmed |
| pubmed-article:6175743 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6175743 | pubmed:articleTitle | Pancreatic acinar cell function: measurement of intracellular ions and pH and their relation to secretion. | lld:pubmed |
| pubmed-article:6175743 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6175743 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6175743 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6175743 | lld:pubmed |
