| pubmed-article:6155080 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C0553695 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C0003387 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C0004259 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C0029904 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C1444748 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C1509144 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C0878412 | lld:lifeskim |
| pubmed-article:6155080 | lifeskim:mentions | umls-concept:C0337051 | lld:lifeskim |
| pubmed-article:6155080 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6155080 | pubmed:dateCreated | 1980-7-22 | lld:pubmed |
| pubmed-article:6155080 | pubmed:abstractText | 45Ca2+ fluxes have been analyzed in dispersed acinar cells prepared from rat pancreas. Sudden addition of carbamylcholine (CCh) to 45Ca2+-preloaded acinar cells at quasi-steady state for 45Ca2+ resulted in a quick 45Ca2+ release followed by a slower 45Ca2+ reuptake with net accumulation of 45Ca2+. Subsequent sudden addition of atropine caused a further transient increase in cellular 45Ca2+ followed by a slow decrease to a steady-state value. 45Ca2+ release could not be evoked a second time by pancreozymin when prestimulated with CCh. However, if CCh stimulation was abolished by an interposed step of atropine, restimulation by cholecystokinin-pancreozymin was possible. Addition of A23187 or antimycin A to cells induced a fast decrease in cellular 45Ca2+. This effect was not additive to the CCh effect. In ouabain-pretreated cells, the CCh-induced sudden loss of cellular 45Ca2+ was blocked by 60%. The following slow reuptake of 45Ca2+ was blocked completely. Subsequent addition of atropine caused a fast uptake of cellular 45Ca2+ with no secondary decline. The data are consistent with the following model: acetylcholine releases Ca2+ from a cellular "trigger pool" into the cytosol located in or near the cell membrane. Then Ca2+ is extruded from the cell via Ca2+ pumps partly by a Na+-dependent Ca2+ transport system (quick phase of 45Ca2+ release). Subsequently, due to increased Ca2+ permeability of the plasma membrane as induced by acetylcholine, Ca2+ influx occurs and Ca2+ is taken up from the cytosol into intracellular Ca2+ pools (slow 45Ca2+ reuptake phase). Atropine causes refilling of the trigger Ca2+ pool and return of the increased Ca2+ permeability of the plasma membrane back to the unstimulated state. | lld:pubmed |
| pubmed-article:6155080 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6155080 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6155080 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6155080 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6155080 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6155080 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6155080 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:6155080 | pubmed:author | pubmed-author:SchulzII | lld:pubmed |
| pubmed-article:6155080 | pubmed:author | pubmed-author:StolzeHH | lld:pubmed |
| pubmed-article:6155080 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6155080 | pubmed:volume | 238 | lld:pubmed |
| pubmed-article:6155080 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6155080 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6155080 | pubmed:pagination | G338-48 | lld:pubmed |
| pubmed-article:6155080 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6155080 | pubmed:meshHeading | pubmed-meshheading:6155080-... | lld:pubmed |
| pubmed-article:6155080 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6155080 | pubmed:articleTitle | Effect of atropine, ouabain, antimycin A, and A23187 on "trigger Ca2+ pool" in exocrine pancreas. | lld:pubmed |
| pubmed-article:6155080 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6155080 | pubmed:publicationType | In Vitro | lld:pubmed |
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