| pubmed-article:6154169 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6154169 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6154169 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6154169 | lifeskim:mentions | umls-concept:C2239176 | lld:lifeskim |
| pubmed-article:6154169 | lifeskim:mentions | umls-concept:C1458155 | lld:lifeskim |
| pubmed-article:6154169 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:6154169 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6154169 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:6154169 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:6154169 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6154169 | pubmed:dateCreated | 1980-6-25 | lld:pubmed |
| pubmed-article:6154169 | pubmed:abstractText | The growth and regression patterns of estrogen (E)-sensitive mammary tumors (SNMU) and autonomous mammary tumors (ANMU) were studied in normal, castrated, and alpha-fetoprotein (AFP)-secreting and nonsecreting hepatoma-bearing female BUF rats. Both SNMU and ANMU tumors had comparable amounts of E receptor. SNMU tumors grew faster in female hosts than in male hosts. The latency period of SNMU tumors was lengthened when the tumor was inoculated into newborn hosts. These E-sensitive tumors regressed after castration of the adult hosts. Tumor regression was also observed in SNMU-bearing rats inoculated with AFP-secreting hepatomas. The growth pattern of the ANMU tumor was not affected by the sex or age of the host. Castration and inoculation of hepatomas to ANMU tumor-bearing rats did not result in regression of the ANMU tumors. We suggest that AFP inhibited the growth of E-sensitive cells in newborn and hepatoma 7777-bearing hosts. This inhibitory effect of AFP could not be attributed to a "functional castration" resulting from the trapping of 17 beta-estradiol (E2) by AFP, because the plasma levels of E2 in these animals affect levels of gonadotropins. Moreover, castration of hepatoma 7777-bearing rats resulted in increased plasma follicle-stimulating hormone and luteinizing hormones levels. The results strongly suggested that a) the malignant properties of E2-sensitive cells in adult hosts can be controlled by AFP, and b) the mechanism by which AFP inhibits the growth of E2-sensitive cells is independent of the E2 "trapping" phenomenon. An ontogenetic approach to the mechanism of action of estrogens may account for available results. | lld:pubmed |
| pubmed-article:6154169 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6154169 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6154169 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6154169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6154169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6154169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6154169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6154169 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6154169 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6154169 | pubmed:month | May | lld:pubmed |
| pubmed-article:6154169 | pubmed:issn | 0027-8874 | lld:pubmed |
| pubmed-article:6154169 | pubmed:author | pubmed-author:SotoA MAM | lld:pubmed |
| pubmed-article:6154169 | pubmed:author | pubmed-author:SonnenscheinC... | lld:pubmed |
| pubmed-article:6154169 | pubmed:author | pubmed-author:UcciA AAA | lld:pubmed |
| pubmed-article:6154169 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6154169 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:6154169 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6154169 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6154169 | pubmed:pagination | 1147-52 | lld:pubmed |
| pubmed-article:6154169 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6154169 | pubmed:meshHeading | pubmed-meshheading:6154169-... | lld:pubmed |
| pubmed-article:6154169 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:6154169 | pubmed:articleTitle | Growth inhibition of estrogen-sensitive rat mammary tumors. Effect of an alpha-fetoprotein-secreting hepatoma. | lld:pubmed |
| pubmed-article:6154169 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6154169 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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