| pubmed-article:6152388 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6152388 | lifeskim:mentions | umls-concept:C0997659 | lld:lifeskim |
| pubmed-article:6152388 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
| pubmed-article:6152388 | lifeskim:mentions | umls-concept:C0061764 | lld:lifeskim |
| pubmed-article:6152388 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6152388 | pubmed:dateCreated | 1985-4-26 | lld:pubmed |
| pubmed-article:6152388 | pubmed:abstractText | The broad-spectrum herbicide glyphosate inhibits the growth of Candida maltosa and causes the accumulation of shikimic acid and shikimate-3-phosphate. Glyphosate is a potent inhibitor of three enzymes of aromatic amino acid biosynthesis in this yeast. In relation to tyrosine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase and dehydroquinate synthase, the inhibitory effect appears at concentrations in the mM range, but 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase is inhibited by micromolar concentrations of glyphosate. Inhibition of partially purified EPSP synthase reaction by glyphosate is competitive with respect to phosphoenolpyruvate (PEP) with a Ki-value of 12 microM. The app. Km for PEP is about 5-fold higher and was 62 microM. Furthermore, the presence of glyphosate leads to derepression of many amino acid biosynthetic enzymes. | lld:pubmed |
| pubmed-article:6152388 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6152388 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6152388 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6152388 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6152388 | pubmed:issn | 0302-8933 | lld:pubmed |
| pubmed-article:6152388 | pubmed:author | pubmed-author:BirnbaumDD | lld:pubmed |
| pubmed-article:6152388 | pubmed:author | pubmed-author:BodoDD | lld:pubmed |
| pubmed-article:6152388 | pubmed:author | pubmed-author:MeliMM | lld:pubmed |
| pubmed-article:6152388 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6152388 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:6152388 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6152388 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6152388 | pubmed:pagination | 83-5 | lld:pubmed |
| pubmed-article:6152388 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6152388 | pubmed:meshHeading | pubmed-meshheading:6152388-... | lld:pubmed |
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| pubmed-article:6152388 | pubmed:meshHeading | pubmed-meshheading:6152388-... | lld:pubmed |
| pubmed-article:6152388 | pubmed:meshHeading | pubmed-meshheading:6152388-... | lld:pubmed |
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| pubmed-article:6152388 | pubmed:meshHeading | pubmed-meshheading:6152388-... | lld:pubmed |
| pubmed-article:6152388 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6152388 | pubmed:articleTitle | Mode of action of glyphosate in Candida maltosa. | lld:pubmed |
| pubmed-article:6152388 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6152388 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6152388 | lld:pubmed |
