| pubmed-article:6149551 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6149551 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:6149551 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:6149551 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:6149551 | lifeskim:mentions | umls-concept:C1817671 | lld:lifeskim |
| pubmed-article:6149551 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:6149551 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:6149551 | lifeskim:mentions | umls-concept:C0085845 | lld:lifeskim |
| pubmed-article:6149551 | lifeskim:mentions | umls-concept:C0080073 | lld:lifeskim |
| pubmed-article:6149551 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:6149551 | pubmed:dateCreated | 1984-12-19 | lld:pubmed |
| pubmed-article:6149551 | pubmed:abstractText | Recognition sites for the excitatory neurotransmitter, L-glutamate, were studied in synaptic plasma membranes and postsynaptic densities (PSDs) isolated from rat brains. The results demonstrate (i) that L-glutamate binding sites may be resolved into three distinct subtypes (categories A1, A2, and A4), each corresponding to an electrophysiologically identified receptor class, and (ii) that the N-methyl aspartate (A1) and quisqualate (A2) receptor types are selectively associated with PSDs. L-[3H]Glutamate bound to an apparently homogeneous population of sites in PSDs with a Kd of 3.39 X 10(-7) M and a Bmax (maximum number of binding sites) of 6.1 pmol/mg of protein. Inhibition studies demonstrated that these sites could be resolved into two distinct subtypes. N-Methyl aspartate maximally inhibited 58% of PSD-located L-glutamate binding sites with a Ki of 7.2 X 10(-6) M (the A1 site), and quisqualate inhibited 42% with a Ki of 1.1 X 10(-6) M (the A2 site); the effects of both substances were additive. Experiments with a range of acidic amino acid analogues indicated that the ligand selectivities of these two binding sites conformed to those of the N-methyl D-aspartate and quisqualate receptor classes defined electrophysiologically. The Cl--dependent population of L-glutamate binding sites (the A4 site), which predominates in synaptic membranes, was absent from isolated PSDs. | lld:pubmed |
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| pubmed-article:6149551 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:6149551 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6149551 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6149551 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6149551 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6149551 | pubmed:author | pubmed-author:FaggG EGE | lld:pubmed |
| pubmed-article:6149551 | pubmed:author | pubmed-author:MatusAA | lld:pubmed |
| pubmed-article:6149551 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6149551 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:6149551 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6149551 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6149551 | pubmed:pagination | 6876-80 | lld:pubmed |
| pubmed-article:6149551 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6149551 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6149551 | pubmed:articleTitle | Selective association of N-methyl aspartate and quisqualate types of L-glutamate receptor with brain postsynaptic densities. | lld:pubmed |
| pubmed-article:6149551 | pubmed:publicationType | Journal Article | lld:pubmed |
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