| pubmed-article:6144343 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6144343 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:6144343 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:6144343 | lifeskim:mentions | umls-concept:C0038590 | lld:lifeskim |
| pubmed-article:6144343 | lifeskim:mentions | umls-concept:C0034798 | lld:lifeskim |
| pubmed-article:6144343 | lifeskim:mentions | umls-concept:C0040615 | lld:lifeskim |
| pubmed-article:6144343 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:6144343 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6144343 | pubmed:dateCreated | 1984-7-18 | lld:pubmed |
| pubmed-article:6144343 | pubmed:abstractText | The activity of neurones in the zona compacta of the rat substantia nigra was recorded extracellularly in vitro. Dopamine produced a dose-dependent depression of firing, threshold doses being in the 3 microM range. The inhibitory effects of dopamine were antagonized by (-)-sulpiride (pA2 7.5), haloperidol (pA2 8.4) and cis-flupenthixol (pA2 6.9). The actions of gamma-aminobutyric acid (GABA) were not affected by these compounds. The gradients of Schild plots of data for (-)-sulpiride were less than unity while those for haloperidol and cis-flupenthixol were greater than unity, which suggests that the antagonism was not competitive. This is discussed with regard to the use of a bioassay system in the analysis of the effects of antagonists. Haloperidol and (-)-sulpiride were found to have similar potencies, as dopamine receptor antagonists, to those predicted from biochemical and clinical efficacy studies, but cis-flupenthixol was less potent than expected. | lld:pubmed |
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| pubmed-article:6144343 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6144343 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6144343 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6144343 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6144343 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6144343 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:6144343 | pubmed:author | pubmed-author:PinnockR DRD | lld:pubmed |
| pubmed-article:6144343 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6144343 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:6144343 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6144343 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6144343 | pubmed:pagination | 631-5 | lld:pubmed |
| pubmed-article:6144343 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6144343 | pubmed:year | 1984 | lld:pubmed |
| pubmed-article:6144343 | pubmed:articleTitle | The actions of antipsychotic drugs on dopamine receptors in the rat substantia nigra. | lld:pubmed |
| pubmed-article:6144343 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6144343 | pubmed:publicationType | In Vitro | lld:pubmed |
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