| pubmed-article:6131799 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6131799 | lifeskim:mentions | umls-concept:C0033147 | lld:lifeskim |
| pubmed-article:6131799 | lifeskim:mentions | umls-concept:C0016976 | lld:lifeskim |
| pubmed-article:6131799 | lifeskim:mentions | umls-concept:C0034813 | lld:lifeskim |
| pubmed-article:6131799 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:6131799 | pubmed:dateCreated | 1983-5-27 | lld:pubmed |
| pubmed-article:6131799 | pubmed:abstractText | The effect of intravenous histamine on intragallbladder pressure (GBp) and subsequent modification of the histamine response by H1- and H2-antagonists was investigated in an awake baboon model. Responses to specific H1- and H2-agonists were also examined in order to further elucidate gallbladder histamine responses. Gallbladder volume (GBv) was arbitrarily set at 60-70% of observed resting GBv, and drugs were then infused intravenously with continuous monitoring of GBp. Histamine administration resulted in a logarithmic dose--response curve with a maximal increase in GBp equal to 31.7 mm Hg at a dose of 0.0625 mg of histamine. Infusion of the H1-antagonist diphenhydramine hydrochloride (Benadryl) resulted in a decreased GBp response to histamine when compared to preblocker response at all doses studied. On the other hand, histamine response following administration of the H2-antagonist metiamide was significantly greater than the preblocker histamine response. Infusion of the H1-agonist 2-pyridylethlamine resulted in a dose-dependent increase in GBp similar to the histamine curve, while infusion of the H2-agonist dimaprit resulted in consistent decreases in GBp. These results extend previous observations in subprimate preparations and demonstrate the presence of both stimulatory H1-receptors and inhibitory H2-receptors in an in situ primate model. | lld:pubmed |
| pubmed-article:6131799 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6131799 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6131799 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6131799 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:6131799 | pubmed:issn | 0163-2116 | lld:pubmed |
| pubmed-article:6131799 | pubmed:author | pubmed-author:BirkettD HDH | lld:pubmed |
| pubmed-article:6131799 | pubmed:author | pubmed-author:WilliamsL... | lld:pubmed |
| pubmed-article:6131799 | pubmed:author | pubmed-author:SchoetzD... | lld:pubmed |
| pubmed-article:6131799 | pubmed:author | pubmed-author:WiseW EWEJr | lld:pubmed |
| pubmed-article:6131799 | pubmed:author | pubmed-author:La MorteW WWW | lld:pubmed |
| pubmed-article:6131799 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6131799 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:6131799 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6131799 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6131799 | pubmed:pagination | 353-8 | lld:pubmed |
| pubmed-article:6131799 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:6131799 | pubmed:meshHeading | pubmed-meshheading:6131799-... | lld:pubmed |
| pubmed-article:6131799 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6131799 | pubmed:articleTitle | Histamine receptors in primate gallbladder. | lld:pubmed |
| pubmed-article:6131799 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6131799 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
